Antitumor Effect of Indomethacin and Telomerase Activity in the Tumor in Colon 26 Bearing CDF1 Mice

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概要

• 論文の詳細を見る

• The antitumor effect of indomethacin on Colon 26 was investigated in vivo and the telomerase activity in the tumor tissues was monitored under chronic indomethacin treatment. Tumor growth was significantly suppressed with indomethacin treatment compared to the controls. In addition, telomerase activity in the tumor tissues markedly declined in contrast to the telomerase activity in the testis and liver, which was not affected by indomethacin treatment. This is the first observation that indomethacin can suppress tumor growth in association with a preferential decrease in telomerase activity in tumor tissues. This study suggests a method to investigate the mechanism(s) of tumor suppression by indomethacin. Furthermore, this study suggests that telomerase activity in the tumor tissues might be a good index to estimate the effectiveness of antitumor agents.

• 日本学士院の論文

著者

• Ogino Mitsuharu

  Department of Obstetrics & Gynecology, Teikyou University, School of Medicine, Ichihara Hospital,

• Hanazono Makoto

  Clinical Research Center Teikyo Unicersity School Of Medicine

• Hisatomi Hisashi

  Center For Molecular Biology And Cytogenetics

• HANZONO Makoto

  Clinical Research Center, Teikyo University School of Medicine, Ichihara Hospital

• OGINO Mitsuharu

  Department of Obstetrics & Gynecology, Teikyo University School of Medicine, Ichihara Hospital

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