<Originals>Modification by steroids of pulmonary oedema and prostaglandin E_2 pharmacokinetics induced by endotoxin in rats

概要

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A single intraperitoneal injection of bacterial endotoxin into rats (3.5 mg・kg^<-1>) caused lung injury assessed as changes in lung dry : wet weight ratio and leukopaenia over the subsequent 28 h. This treatment also slowed the efflux of ^<14>C from [^<14>C]-prostaglandin E_2 in isolated perfused lungs over the same period. These effects of endotoxin were reversed by methylprednisolone (30 mg・kg^<-1>), given 30 min after the endotoxin. Another synthetic corticosteroid, budesonide, given at 1.2 mg・kg^<-1>, 1 h before endotoxin partially prevented the lung injury and leukopaenia but did not affect the increased t_<1/2> of prostaglandin E_2 nor its survival. The reversal by methylprednisolone of both the physical signs of lung injury and the changes in prostaglandin E_2 pharmacokinetics caused by endotoxin could serve as an index of acute lung injury following sepsis.
近畿大学の論文