Sentinel Node Navigation Surgery in Early-Stage Esophageal Cancer
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概要
- 論文の詳細を見る
The sentinel node (SN) concept has revolutionized the surgical staging of both melanoma and breast cancer over the past two decades. However, the validity of the SN hypothesis has been controversial for esophageal cancer, because SN mapping for esophageal cancer is technically complicated, and the number of early-stage esophageal cancer is very limited. Nevertheless previous studies nicely demonstrated that SN mapping may be feasible in patients with early-stage esophageal cancer. Transthoracic extended esophagectomy with three-field radical lymph node dissection has been recognized as a curative procedure for thoracic esophageal cancer in Japan. However, uniform application of this highly invasive procedure might increase the morbidity and markedly reduce the quality of life (QOL) after surgery. Although further accumulation of evidence based on multicenter clinical trials using a standard protocol is needed, SN mapping and SN navigation surgery would provide significant information to perform individualized selective lymphadenectomy which might reduce the morbidity and retain the patients’ QOL. In addition, technical innovation including the development of new tracers is expected to confirm the accuracy and reliability of SN mapping in esophageal cancer.
- 2012-08-01
著者
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Omori Tai
Department Of Surgery Kawasaki Municipal Hospital
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Kitagawa Yuko
Department Of Food Science And Technology School Of Agriculture Nagoya University
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Takeuchi Hiroya
Department Of Surgery Keio University School Of Medicine
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Kawakubo Hirofumi
Department Of Surgery Kawasaki Municipal Hospital
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Takeda Flavio
Department Of Head And Neck Surgery Hospital Das Clinicas University Of Sao Paulo Medical School
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OMORI Tai
Department of Surgery, Keio University School of Medicine
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KAWAKUBO Hirofumi
Department of Surgery, Keio University School of Medicine
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TAKEDA Flavio
Department of Gastroenterology, Digestive Surgery Division, Esophageal Group, University of Sao Paulo School of Medicine and Sao Paulo Institute of Cancer
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