Immunomodulatory Effects of Xylooligosaccharides

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概要

• 論文の詳細を見る

• Xylooligosaccharides (XOs) are considered as food ingredients, and exhibit the prebiotic effects related to gut modulation. However, no related research is available to explain their immunomodulatory effects. This report elucidated their immunomodulatory effects through the variations of proinflammatory mediators in vitro. We found that XOs (0.1 − 100 μg/mL) induced tumor necrosis factor alpha (TNF-α), IL-1β, IL-6 and nitric oxide (NO) production in un-stimulated macrophages, RAW264.7 cells. Furthermore, pre- and post-treated XOs (0.1−100 μg/mL) dose-dependently suppressed TNF-α, IL-1β, IL-6 and NO production and induced IL-10 production in lipopolysaccharide (LPS)-stimulated RAW264.7 cells without exerting cytotoxicity. Of note is that prostaglandin E2 (PGE2) production didn’t change significantly through the XOs treatment. These data demonstrate that XOs potently down-regulates the LPS-induced inflammatory response. The in vitro assessment of inflammatory mediators should be useful in further characterization of the effects of XOs on immunomodulation.

• 2012-03-01

著者

• Chang Hung

  Department of Food Science & Technology, Faculty of Agriculture,Kyushu University

• CHEN HUA

  Department of Computer Science & Technology, Tsinghua University

• Chen Yu

  Department Of Chemical Biology Ernest Mario School Of Pharmacy Rutgers The State University Of New Jersey

• Chen Hua

  Department Of Food Science National Penghu University Of Science And Technology

• Lin Su

  Department Of Applied Science Of Living Chinese Culture University

• Chen Yu

  Department And Graduate School Of Physical Education National Taiwan College Of Physical Education

• CHEN Hua

  Department of Burns, The People's Hospital of Guangdong Province

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