Effect of the Uncharged Imidazolium Moiety in Adenine on Endothelium-Independent Relaxation in the Contracted Thoracic Aorta of Sprague-Dawley Rats

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概要

• 論文の詳細を見る

• Adenine had a concentration-dependent relaxation action on the phenylephrine-contracted aorta ring, with an EC<SUB>50</SUB> value of 0.40±0.12 mM. This effect was also observed in the endothelium-denuded aorta. Among the adenine analogues, <I>N</I>-methyladenine and benzimidazole still evoked an apparent relaxation effect, while 1-, 3- or 7-methyladenine and imidazole were no longer vasodilators. These findings demonstrate that the imino group from the uncharged imidazolium moiety in adenine played a key role in the relaxation of the contracted aorta.

• 2012-04-23

著者

• Matsui Toshiro

  Division Of Bioresources And Biosciences Faculty Of Agriculture Graduate School Of Kyushu University

• Tokuda Shinji

  Division Of Bioresources And Biosciences Faculty Of Agriculture Graduate School Of Kyushu University

• Tanaka Mitsuru

  Division Of Bioresources And Biosciences Faculty Of Agriculture Graduate School Of Kyushu University

• Fukuda Toshihiko

  Division Of Bioresources And Biosciences Faculty Of Agriculture Graduate School Of Kyushu University

• KOBAYASHI Yutaro

  Division of Bioresources and Biosciences, Faculty of Agriculture, Graduate School of Kyushu University

• Kobayashi Yutaro

  Division Of Bioresources And Biosciences Faculty Of Agriculture Graduate School Of Kyushu University

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