Evolution of two Rh blood group-related genes of the amphioxus species Branchiostoma floridae
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概要
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We determined cDNAs of two genes that belong to the Rhesus (Rh) blood group gene family in an amphioxus species (Branchiostoma floridae) and designated them Rh-related-1 (RhR-1) and Rh-related-2 (RhR-2). RhR-1 and RhR-2 consisted of 10 and 11 exons, respectively. 3’ UTR sequences of RhR-1 were shorter (220–272 bp) than those of RhR-2 (1,505–1,650 bp). CDS lengths were 1,344 and 1,476 bp for RhR-1 and RhR-2, respectively, and the average nucleotide difference between their CDS regions was 0.33. The corresponding regions of Rh genes from exons 2 to 7 were relatively conserved among the chordate species examined in this study. Length difference numbers were in multiples of three, which implies that codon frames were conserved among them, and the same exon/intron boundary phases were observed in those regions. This region was used for the phylogenetic analyses. RhR-1 and RhR-2 formed a cluster on the phylogenetic tree of the Rh gene family. Gene duplication time of RhR-1 and RhR-2 was estimated to be ca. 500 million years ago. It is likely that the four Rh family genes in vertebrates emerged by gene duplications in the common ancestor of vertebrates, and functional differentiation has occurred after the first gene duplication.
- 日本遺伝学会の論文
- 2010-04-25
著者
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北野 誉
山形大学医学部環境病態統御学講座法医病態診断学分野
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Saitou Naruya
Division Of Population Genetics National Institute Of Genetics
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Koide Tsuyoshi
Mammalian Genetics Laboratory National Institute Of Genetics
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北野 誉
弘前大学大学院理学研究科
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北野 誉
茨城大学工学部生体分子機能工学科
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Kitano Takashi
Dep. Of Biomolecular Functional Engineering Coll. Of Engineering Ibaraki Univ.
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Kitano Takashi
Division Of Population Genetics National Institute Of Genetics
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Satou Masahiro
Department of Biomolecular Functional Engineering, College of Engineering, Ibaraki University
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Kitano Takashi
Department Of Biology Faculty Of Science Hirosaki University Laboratory Of Evolutionary Genetics Nat
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Kitano Takashi
Department Of Biomolecular Functional Engineering College Of Engineering Ibaraki University
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Satou Masahiro
Department Of Biomolecular Functional Engineering College Of Engineering Ibaraki University
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