Occurrence and Clinical Features of Brain Metastasis after Chemoradiotherapy for Esophageal Carcinoma
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概要
- 論文の詳細を見る
Brain metastasis from esophageal carcinoma has been considered rare and survival following esophageal carcinoma with distant metastasis is poor. The purpose of this report was to clarify cumulative incidence and risk factors for brain metastasis after chemoradiotherapy for esophageal carcinoma, and to consider recommended treatments for brain metastasis from esophageal carcinoma. We reviewed 391 patients treated with chemoradiotherapy. Median age was 65 years. Clinical stages were I, II, III, and IV in 32, 47, 150, and 162 patients, respectively. Brain imaging was performed usually when patients revealed neurological symptoms. The 3-year cumulative incidence of brain metastasis after chemoradiotherapy was 6.6%. There were 4 patients with single metastasis and 8 with multiple metastases. Initial clinical stages were II, III, and IV in 1, 2, and 9 patients, respectively. Histology included squamous cell carcinoma in 10 patients and others in 2 patients. Univariate analysis demonstrated M factor, distant lymph node relapse, and recurrent lung and liver metastasis as significant risk factors of brain metastasis (P < 0.05). Median survival time after diagnosis of brain metastasis was 2.1 months. Brain metastasis was not directly related to cause of mortality. The causes were extracranial tumor deterioration in 8 patients and infection in 4 patients. Brain metastasis may increase in the future with improving survival from esophageal carcinoma. However, considering the poor survival after diagnosis of brain metastasis, short-term palliative therapy for brain metastasis appears preferable to vigorous long-term therapy.
- Journal of Radiation Research 編集委員会の論文
- 2011-07-16
著者
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原田 英幸
静岡県立静岡がんセンター放射線治療科
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Boku Narikazu
Division Of Digestive Endoscopy And Gastrointestinal Oncology National Cancer Center Hospital East
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Harada Hideyuki
Division Of Radiation Oncology Shizuoka Cancer Center
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Furutani Kazuhisa
Division Of Radiation Oncology Shizuoka Cancer Center
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Nakasu Yoko
Division Of Neurosurgery Shizuoka Cancer Center
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Nishimura Tetsuo
Division Of Radiation Oncology Shizuoka Cancer Center
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Asakura Hirofumi
Division Of Radiation Oncology Shizuoka Cancer Center
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Ono Hiroyuki
Division Of Gastrointestinal Endoscopy Of Shizuoka Cancer Center
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Hashimoto Takayuki
Division Of Radiation Oncology Shizuoka Cancer Center Hospital
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KANEMOTO Ayae
Division of Radiation Oncology, Shizuoka Cancer Center Hospital
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OGAWA Hirofumi
Division of Radiation Oncology, Shizuoka Cancer Center Hospital
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Kanemoto Ayae
Division Of Radiation Oncology Shizuoka Cancer Center Hospital
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Boku Narikazu
Division Of Gastrointestinal Oncology Shizuoka Cancer Center Hospital
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Ono Hiroyuki
Division Of Radiation Oncology Shizuoka Cancer Center Hospital
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Hashimoto Takayuki
Division Of Radiation Oncology Shizuoka Cancer Center
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Nishimura Tetsuo
Division Of Radiation Oncology Shizuoka Cancer Center Hospital
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Harada Hideyuki
Division Of Radiation Oncology Shizuoka Cancer Center Hospital
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NISHIMURA TETSUO
Division of Radiation Oncology, Shizuoka Cancer Center Hospital
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