Pleomorphic Xanthoastrocytoma and Moyamoya Disease in a Patient With Neurofibromatosis Type 1 : Case Report
スポンサーリンク
概要
- 論文の詳細を見る
A 32-year-old man with familial neurofibromatosis type 1 presented with a rare case of coexisting pleomorphic xanthoastrocytoma (PXA) and moyamoya disease manifesting as progressive right hemiparesis. Magnetic resonance (MR) imaging with gadolinium showed an enhanced mass lesion in the left basal ganglia extending to the left parietal lobe. Preoperative angiography showed severe stenosis of the bilateral internal carotid arteries, and moyamoya vessels. The patient underwent open biopsy. Histological examination showed the characteristic findings of PXA. After radiation therapy and chemotherapy, MR imaging showed decreased size and enhancement of the tumor, but his clinical condition worsened with generalized convulsions and consciousness disturbance. He died 1 year and 6 months after the first presentation. Autopsy findings demonstrated necrosis in the main mass and tumor cell dissemination without anaplastic change. The rare combination of PXA and moyamoya disease in the basal ganglia limited treatment options. Injured moyamoya vessels and ischemic condition might have caused tumor progression and dissemination. Radiation therapy, in combination with moyamoya disease, induced decreased cerebral blood flow (CBF) in the left frontal lobe. Tumor dissemination, CBF decrease, and hydrocephalus led to the clinical deterioration of this patient.
- 2011-04-15
著者
-
WATANABE Reiko
Division of Hematology, Department of Internal Medicine, Saitama Medical Center
-
YAGISHITA Saburo
Division of Pathology, Kanagawa Rehabilitation Center
-
Yagishita Saburo
Division Of Pathology (neuropathology) Kanagawa Rehabilitation Center
-
Horiguchi Satoshi
Divisions Of Neurosurgery Shizuoka Cancer Center
-
Nakasu Yoko
Division Of Neurosurgery Shizuoka Cancer Center
-
Mitsuya Koichi
Division Of Neurosurgery Shizuoka Cancer Center Hospital
-
Horiguchi Satoshi
Division Of Neurosurgery Shizuoka Cancer Center
-
Watanabe Reiko
Division Of Hematology Department Of Internal Medicine Saitama Medical Center
-
Mitsuya Koichi
Division Of Neurosurgery Shizuoka Cancer Center
関連論文
- Melanocytic medulloblastoma with ganglioneurocytomatous differentiation : A case report
- Severe degenerative change of multiple organs mediated by chronic active Epstein-Barr virus infection with infected T-cell expansion
- Pituicytoma : Two Case Reports
- Neuropathology of progressive supranuclear palsy
- Tissue Plasminogen Activator Levels After Single Intracisternal Injection in Patients With Subarachnoid Hemorrhage
- Autopsy case of Creutzfeldt-Jakob disease with Met/Val heterozygosity at codon 129 and type 1 protease-resistant prion protein presenting some florid-type plaques and many Kuru plaques in the cerebellum
- Ectopic Growth Hormone-Releasing Adenoma in the Cavernous Sinus : Case Report
- Distribution and dynamic process of neuronal cytoplasmic inclusion (NCI) in MSA : Correlation of the density of NCI and the degree of involvement of the pontine nuclei
- Pleomorphic Xanthoastrocytoma and Moyamoya Disease in a Patient With Neurofibromatosis Type 1 : Case Report
- Glutamate Receptor Antagonists and Benzodiazepine Inhibit the Progression of Granule Cell Dispersion in a Mouse Model of Mesial Temporal Lobe Epilepsy
- An Autopsy Case of so-called Microgliomatosis
- Occurrence and Clinical Features of Brain Metastasis after Chemoradiotherapy for Esophageal Carcinoma
- Familial motor neuron disease with prominent onion-bulb-like structures and axonal swelling restricted to the spinal ventral root : autopsy findings in two siblings
- Radiotherapy for Patients with Symptomatic Intramedullary Spinal Cord Metastasis
- Leptomeningeal carcinomatosis associated with gastric cancer
- Detection of Tumor Progression by Signal Intensity Increase on Fluid-Attenuated Inversion Recovery Magnetic Resonance Images in the Resection Cavity of High-Grade Gliomas
- Papillary Squamous Cell Carcinoma of the Trachea Associated with Human Papillomavirus-18 Infection
- Detection of Tumor Progression by Signal Intensity Increase on Fluid-Attenuated Inversion Recovery Magnetic Resonance Images in the Resection Cavity of High-Grade Gliomas