ACE阻害剤による口腔底および顎下部の晩発性血管浮腫例

概要

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Angioedema, occurring in the pharynx and induced by Angiotensin-Converting Enzyme inhibitor (ACEi), is life-threatening and requires emergency treatment. A 69-year old woman referred for recurrent oral edema and neck swelling had been taking oral ACEi due to hypertension for over 5 years. She had no history of food allergy or marked family history. Examination showed soft diffuse bilateral oral floor swelling with normal-color mucosa. She did not report dyspnea, dysphagia, or pain. Blood tests showed normal levels of C3, C4, CH50, and C1 inhibitor function. Although most ACEi-associated angioedema occurs within the first week of administration, we diagnosed angioedema due to ACEi based on laboratory results. Once ACEi administration was stopped, oral floor swelling disappeared. It is thus important in angioedema treatment to check oral medication.
2011-04-01