Spontaneous Pituitary Carcinoma of the Pars Intermedia in a B6C3F1 Mouse
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概要
- 論文の詳細を見る
We encountered one pituitary carcinoma derived from the pars intermedia in an untreated female B6C3F1 mouse in a carcinogenicity study. A white nodule (6 × 5 × 3 mm) was observed in the base of the brain at necropsy. Tumor cells were histologically arranged in a solid sheet or nest-like structures, and had round or oval nuclei and pale eosinophilic granular cytoplasm. Sporadic mitotic figures were seen in the tumor while necrosis was a prominent feature. In addition, distinct infiltration into the brain parenchyma was observed. Immunohistochemically, tumor cells were positive for α-melanocyte stimulating hormone (α-MSH), γ-melanocyte stimulating hormone (γ-MSH), β-endorphin and adenocorticotropic hormone (ACTH), but were negative for prolactin. However, there were no histological abnormalities such as adrenocortical hyperplasia related to the pars intermedia tumor. These results suggest that the tumor cells might not have actively secreted proopiomelanocortin (POMC)-derived peptides. The present report provides additional histopathological evidence of pituitary carcinoma of the pars intermedia in aging mice.
- 日本毒性病理学会の論文
- 2008-06-30
著者
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IWATA Hijiri
Biosafety Research Center
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Imai Kiyoshi
Biosafety Research Center Foods Drugs And Pesticides
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Hosoi Masayo
Biosafety Research Center Food Drugs And Pesticides
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Iwata Hijiri
Biosafety Research Center Foods Drugs And Pesticides (an-pyo Center)
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Shiga Atsushi
Biosafety Research Center Foods Drugs And Pesticides (an-pyo Center)
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Yamashita Ryo
Biosafety Research Center Food Drugs And Pesticides
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Ishizaki Mayumi
Biosafety Research Center Food Drugs And Pesticides
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Imai Kiyoshi
Biosafety Research Center Foods Drugs And Pesticides (an-pyo Center)
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Ueda Yoshihide
Biosafety Research Center, Foods, Drugs and Pesticides (BSRC)
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Miyajima Rumiko
Biosafety Research Center, Foods, Drugs and Pesticides (BSRC)
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Hasegawa Kazushige
Biosafety Research Center, Foods, Drugs and Pesticides (BSRC)
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YASUI Yuzo
Biosafety Research Center, Foods Drugs and Pesticides (An-Pyo Center)
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NAGAI Kayoko
Biosafety Research Center, Foods Drugs and Pesticides (An-Pyo Center)
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KIHARA Tohru
Biosafety Research Center, Foods Drugs and Pesticides (An-Pyo Center)
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Hasegawa Kazushige
Biosafety Research Center Foods Drugs And Pesticides (an-pyo Center)
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Yasui Yuzo
Biosafety Research Center Foods Drugs And Pesticides (an-pyo Center)
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Nagai Kayoko
Biosafety Research Center Foods Drugs And Pesticides (an-pyo Center)
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Kihara Tohru
Biosafety Research Center Foods Drugs And Pesticides (an-pyo Center)
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Miyajima Rumiko
Biosafety Research Center Foods Drugs And Pesticides (an-pyo Center)
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Ueda Yoshihide
Biosafety Research Center Foods Drugs And Pesticides (bsrc)
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