Identification of Novel L-Amino Acid α-Ligases through Hidden Markov Model-Based Profile Analysis

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概要

• 論文の詳細を見る

• L-Amino acid α-ligase (Lal), catalyzing the formation of α-dipeptides from unprotected L-amino acids in an ATP-dependent manner, is used in cost-effective fermentative production of dipeptides. We searched for novel Lals by in silico screening using Hidden Markov Model-based profile analysis, and identified five novel Lals that showed low similarity and different substrate specificity from known Lals.

• 社団法人 日本農芸化学会の論文
• 2010-02-23

著者

• Yagasaki Makoto

  Technical Research Laboratories, Kyowa Hakko Bio Co., Ltd.

• Yagasaki Makoto

  Technical Research Laboratories Kyowa Hakko Bio Co. Ltd.

• SENOO Akihiro

  Bioprocess Development Center, Kyowa Hakko Bio Co., Ltd.

• TABATA Kazuhiko

  Bioprocess Development Center, Kyowa Hakko Bio Co., Ltd.

• YONETANI Yoshiyuki

  Bioprocess Development Center, Kyowa Hakko Bio Co., Ltd.

• Yonetani Yoshiyuki

  Bioprocess Dev. Center Kyowa Hakko Bio Co. Ltd.

• Yonetani Yoshiyuki

  Bioprocess Development Center Kyowa Hakko Bio Co. Ltd.

• Senoo Akihiro

  Bioprocess Development Center Kyowa Hakko Bio Co. Ltd.

• Tabata Kazuhiko

  Bioprocess Development Center Kyowa Hakko Bio Co. Ltd.

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