Transcriptome Analysis Reveals Global Expression Changes in an Industrial L-Lysine Producer of Corynebacterium glutamicum
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概要
- 論文の詳細を見る
Toward the elucidation of advanced mechanisms of L-lysine production by Corynebacterium glutamicum, a highly developed industrial strain B-6 was analyzed from the viewpoint of gene expression. Northern blot analysis showed that the lysC gene encoding aspartokinase, the key enzyme of L-lysine biosynthesis, was up-regulated by several folds in strain B-6, while no repression mechanism exists in L-lysine biosynthesis of this bacterium. To analyze the underlying mechanisms of the up-regulation, we compared the transcriptome between strain B-6 and its parental wild-type, finding that not only lysC but also many other amino acid-biosynthetic genes were up-regulated in the producer. These results suggest that a certain global regulatory mechanism is involved in the industrial levels of L-lysine production.
- 社団法人 日本農芸化学会の論文
- 2006-02-23
著者
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IKEDA Masato
Department of Occupational Health Economics, University of Occupational and Environmental Health
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Hayashi Mikiro
Biofrontier Laboratories Kyowa Hakko Kogyo Co. Ltd.
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Ikeda Masato
Biofrontier Laboratories Kyowa Hakko Kogyo Co. Ltd.
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Hashimoto Shin-ichi
Technical Research Laboratories Kyowa Hakko Kogyo Co. Ltd.
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Ikeda Masato
Department Of Chemistry & Biochemistry Graduate School Of Engineering Kyushu University
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OHNISHI Junko
Biofrontier Laboratories, Kyowa Hakko Kogyo Co., Ltd.
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MITSUHASHI Satoshi
Biofrontier Laboratories, Kyowa Hakko Kogyo Co., Ltd.
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YONETANI Yoshiyuki
Biofrontier Laboratories, Kyowa Hakko Kogyo Co., Ltd.
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Ohnishi Junko
Biofrontier Laboratories Kyowa Hakko Kogyo Co. Ltd.
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Yonetani Yoshiyuki
Bioprocess Dev. Center Kyowa Hakko Bio Co. Ltd.
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Ikeda Masato
Department Of Bioscience And Biotechnology Faculty Of Agriculture Shinshu University
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