子宮内膜症におけるMAPKを介する炎症の解析と新たな治療戦略

概要

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Given the current theory of inflammatory changes being involved in the progression of endometriosis, MAPKs might be at play as pivotal intracellular signal transducers in endometriotic cells and thus have a pathophysiological role in the disease. In vitro study using endometriotic cell, all the MAPK inhibitors examined suppressed IL-1β-induced secretion of IL-6 and IL-8, and IL-1β-induced expression of COX-2 in endometriotic cells. Among MAPK inhibitors, p38MAPK inhibitor seemed to have the best potential to block inflammation. Then, the authors evaluated the effect of FR 167653, a p38MAPK inhibitor, on the development of endometriotic lesions and on the intraperitoneal inflammatory status using experimental model mice for endometriosis. FR 167653, a p38 MAPK inhibitor, caused a reduction in the growth of endometriotic lesions, coupled with the suppression of intraperitoneal inflammation. Thus, p38 MAPK inhibitors could have the therapeutic potential for endometriosis.
日本炎症・再生医学会の論文
2004-11-25