Retinopathy : An Overlooked Adverse Effect of Interferon-beta Treatment of Multiple Sclerosis
スポンサーリンク
概要
- 論文の詳細を見る
Interferon (IFN), which is an established maintaining therapy for multiple sclerosis (MS), has been reported various adverse effects. This paper describes a case of IFN-associated retinopathy, representing an overlooked adverse effect in MS. A 46-year-old woman with diabetes mellitus was diagnosed with MS and treated with IFNβ-1b for three years. She displayed sudden defect of the visual field and ocular fundi showed retinal cotton wool spots indicating IFN-retinopathy, which resolved rapidly after IFN was discontinued. To evaluate the prevalence of retinopathy in MS, we performed fundoscopic examination on twenty MS patients treated with IFNβ-1b in our hospital. However, none of the patients displayed retinopathy. Only four other cases of IFN- retinopathy in MS have been reported in the literature. Therefore, IFN-retinopathy may be uncommon in MS, but neurologist should be mindful of this adverse effect and regularly check the fundus, particularly in patients with possible risk factor, diabetes mellitus.
- The Keio Journal of Medicineの論文
- 2009-03-01
著者
-
ITO Daisuke
Department of Surgery and Surgical Basic Science, Kyoto University
-
Suzuki Norihiro
Department Of Neurology School Of Medicine Keio University
-
Shimizu Toshihiko
Department Of Neurology School Of Medicine Keio University
-
Shimizu Toshihiko
Department Of Neurology Keio University
-
Ohde Hisao
Department Of Ophthalmology School Of Medicine Keio University
-
Ohde Hisao
Department Of Ophthalmology Keio University School Of Medicine
-
Suzuki Norihiro
Department Of Dermatology Okayama University Graduate School Of Medicine Dentistry And Phartmaceutic
-
Shibata Mamoru
National Hospital Organization Tokyo Medical Center
-
OHIRA Masayuki
Department of Neurology, School of Medicine, Keio University
-
Ohira Masayuki
Department Of Neurology School Of Medicine Keio University
-
Ito Daisuke
Department Of Mechanical Science And Engineering Nagoya University
-
Ito Daisuke
Department Of Neurology School Of Medicine Keio University
-
Ito Daisuke
Department Of Applied Materials Science. Graduate School Of Eneineerine. Osaka Prefecture University
-
Ito Daisuke
Department Of Advanced Bioscience Faculty Of Agriculture Kinki University
-
ITO Daisuke
Department of Neurology, School of Medicine, Keio University
関連論文
- 4 On-going Japanese Clinical Trials for Hypertension II : Seeking for More Effective Pharmacological Treatment(ESC-JCS Joint Symposium (ESC-JCS Joint Symposium) (H) Evidence-Based Medical Treatment of Hypertension,Special Program,The 72nd Annual Scientifi
- Corticobasal degeneration as cause of progressive non-fluent aphasia : Clinical, radiological and pathological study of an autopsy case
- Analysis of E-, N-Cadherin, α-, β-, and γ-Catenin Expression in Human Pancreatic Carcinoma Cell Lines
- Refolding of Denatured and Reduced Lysozyme with Cysteine/Cystine Red/Ox Solution in Diafiltration
- Refolding of Denatured/Reduced Lysozyme at High Concentration with Diafiltration
- Genetic Variants of TP53 and EPHX1 in Leber's Hereditary Optic Neuropathy and Their Relationship to Age at Onset
- Macular Nerve Fibers Temporal to Fovea May Have a Greater Potential to Recover Function in Patients With Leber's Hereditary Optic Neuropathy
- Clinical and Laboratory Features of in-Patients with Multiple Sclerosis in a University Hospital in Tokyo from 1988-2002
- Improvement of Surface Morphology and Dielectric Property of YMn0_3 Films
- Epidermolysis bullosa nevus arising in a patient with Dowling-Meara type epidermolysis bullosa simplex with a novel K5 mutation
- Induction of Inducible Nitric Oxide Synthase Affects the Function of Blood-Brain Barrier in the Rat
- Bilateral Acute Functional Disturbance in the Retina Following Placental Abruption
- Pion Production in Pion-Nucleon Collision with Assumption of Strong Pion-Pion Interaction
- Plasma excitatory amino acid levels in multiple system atrophy
- Plasma homocysteine level in multiple system atrophy
- Altered levels of serotonin in lymphoblasts derived from migraine patients
- A Constitutive Model for Skeletal Muscle Taking Account of Anisotropic Damage and Viscoelasticity(2C1 Musculo-Skeletal Biomechanics IV)
- Pathological and Mechanical Evaluations of Skeletal Muscle Injury by Impact Load(Micro- and Nano-biomechanics)
- A Case of Poorly Differentiated Hilar Lung Adenocarcinoma of an Unidentified Histological Type
- Alterations in G1 Phase Cell Cycle Regulation during the Development of Benzo[a]pyrene-induced Epithelial Dysplasia in the Murine Tongue
- Identification and evaluation of high-titer anti-Sox Group B antibody in limbic encephalitis
- Effects of Telmisartan on Insulin Resistance in Japanese Type 2 Diabetic Patients
- Regulation of Cerebral Microcirculation-Update
- Uncoupling of cerebral blood flow and glucose utilization in the regenerating facial nucleus after axotomy
- Retinopathy : An Overlooked Adverse Effect of Interferon-beta Treatment of Multiple Sclerosis
- Optical Properties of SnTe
- Optical Properties of PbTe
- A Composite System with Linear Trajectory
- Occurrence and Distribution of GABA_A Receptors β Subunit in Cerebral Blood Vessels and Cranial Ganglia of the Rat
- Thermal Response of Poly(N - n - propylacrylamide)
- The Work-Hardening Process in Metals
- Anomalous Scattering Behavior of Poly(N-n-propylacrylamide) in 2-Propanol/Water
- Variational Principle in Dynamical S-Matrix Theory. I
- Epidemiological Features of Moyamoya Disease in Japan
- A Comparative Analysis of the Molecular Characteristics of the Arabidopsis CoA Pyrophosphohydrolases AtNUDX11, 15, and 15a
- An Arabidopsis FAD Pyrophosphohydrolase, AtNUDX23, is Involved in Flavin Homeostasis
- Differential Diagnosis Between Intracranial Dissemination of Spinal Cord Astrocytoma and Paraneoplastic Limbic Encephalitis
- Multidetector Computed Tomography Demonstrates Double-Inlet, Double-Outlet Right Ventricle
- Room-Temperature Hydrogen Sensing Properties of SnO2 Thin Films Fabricated by the Photochemical Deposition and Doping Methods
- "Superior Rectus Paralysis" due to Inferior Rectus Myxedema
- Inflammatory Myopathy with Anti-Golgi Antibody and Anti-SS-A/Ro Antibody
- Multifocal Magnetoencephalogram Aplied to Objective Visual Field Analysis
- Enzymatic and Molecular Characterization of Arabidopsis ppGpp Pyrophosphohydrolase, AtNUDX26
- Impairment of CO2 reactivity in RBC velocity and CBF after cortical spreading depression in anesthetized mice
- Systolic blood pressure at admission, clinical manifestations, and in-hospital outcomes in patients with acute myocardial infarction
- Prognostic impact of systolic blood pressure at admission on in-hospital outcome after primary percutaneous coronary in tervention for acute myocardial infarction
- A Conjecture on the Origin of Spring Force in Quark Oscillator Model