Occurrence and Distribution of GABA_A Receptors β Subunit in Cerebral Blood Vessels and Cranial Ganglia of the Rat

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Valproate (2-propylpentanoid acid) has been reported to be useful and effective prophylactic agent for migraine. Although its pharmacological mechanism in migraine is obscure, it is speculated that increased GABA might suppress the neurogenic inflammation in the pathogenesis of migraine. We explored the occurrence and the distribution of GABA_A receptors β subunit using the immunohistochemistrical method in major cerebral arteries and cranial ganglia, i.e., trigeminal (TG), superior cervical (SCG), sphenopalatine (SPG) and otic ganglia (OTG), which are known to be the origin of the cerebrovascular innervation. GABA_A receptors immunoreactivity was found along the perivascular nerve fibers in cerebral arteries of the rat. The fine fibers were observed particularly in the circle of Willis, while the thick bundle fibers were notable in the basilar arteries. In cross sections, GABA_A receptors immunoreactivity was observed not only in the adventitia but also in the inthima. In the cranial ganglia, GABA_A receptors immunoreactivity was recognized around the ganglion cells and blood vessels as well as in the cell membrane of the neurons. Its density was remarkably higher in SCG, OTG and SPG than in TG. The present study suggests that GABAergic system modulates the autonomic nerves, i. e., sympathetic and/or parasympathetic nerves rather than sensory nerves in the peripheral nervous system. These results imply certain involvement of GABAergic system in the pathophysiology of vascular headache such as migraine.
北里大学の論文
1999-12-31

Occurrence and Distribution of GABA_A Receptors β Subunit in Cerebral Blood Vessels and Cranial Ganglia of the Rat

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