非侵襲計測のための皮膚成分抽出法の検討

概要

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We have focused on skin as an information source of the cholesterol level from a living body. In this study, skin components were extracted by placing a palm in contact with an organic solvent. The resulting solution was analyzed by using high-performance liquid chromatography. Some important parameters, such as the extracting time, area and solvent, in extracting skin components were investigated. Cholesterol, cholesterol oxide and suqualene were extracted from skin by using ethanol as an extracting solvent. The concentration of skin cholesterol was higher along with an increase in the extracting time, and because saturated after 60 s. A plastic cup (diameter ; 4.2 cm ; extract area : 12.8 cm2) was appropriate for extracting skin cholesterol to discriminate individual difference and easiness in handling. The concentration of skin cholesterol correlated with the amount of blood cholesterol measured by a medical institution, which suggests that this method has potential usefulness for non-invasive cholesterol measurements.
2010-03-05