肝細胞造影相を利用した肝機能情報の取得法に関する検討

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In a field of contrast-enhanced magnetic resonance imaging of the liver, attention has been focused on evaluation of liver function using gadolinium ethoxybenzyl diethylenetriaminepentaacetic acid(EOB). In this study, we examined the possibility of obtaining liver function in only one hepatobiliary phase 60 minutes after injection. First, in regard to the difference between the signal intensity of two materials, we examined the effects of slice gap, surface coil intensity correction(SCIC), and others. Secondly, we compared the difference between liver and spleen signal intensity with biochemical laboratory tests, Child-Pugh class, liver damage class, and the two indices(HH15 and LHL15)calculated by 99mTc-DTPA-galactosyl-human serum albumin hepatic scintigraphy in patients with chronic liver diseases. Finally, we designated the “Liver EOB uptake index(L-EOB60)” from those results, compared with HH15 and LHL15. The results demonstrated that the difference between the signal intensity of two materials increased in the lack of slice gap explained by cross talk, and decreased with SCIC. The difference between liver and spleen signal intensity decreased with worsened liver and kidney function. In the case of slice gap >20% and direct bilirubin <0.5 mg/dL without SCIC, the correlation coefficient between L-EOB60 and LHL15 was 0.97. L-EOB60 was strongly proportional to LHL15. We conclude that L-EOB60 meeting the above conditions can be employed as a useful index to determine liver function.
社団法人　日本放射線技術学会の論文
2009-11-20

肝細胞造影相を利用した肝機能情報の取得法に関する検討

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