The hOGG1 Ser326Cys Polymorphism Is Not Associated with Colorectal Cancer Risk
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概要
- 論文の詳細を見る
BACKGROUND: Little is known about the genetic risk factors associated with colorectal cancer. Although the Ser326Cys polymorphism of 8-oxoguanine DNA glycosylase (hOGG1) is consistently associated with a range of cancers, there is no consensus regarding this polymorphism and colorectal cancer risk.METHODS: In the present study, conducted in a Korean population, we used the TaqMan assay to investigate whether the hOGG1 Ser326Cys polymorphism was associated with colorectal cancer in 439 colorectal cancer patients and 676 healthy normal controls. We also examined whether the hOGG1 Ser326Cys polymorphism is associated with tumor location, microsatellite instability (MSI) status and tumor-node-metastasis (TNM) stage in colorectal cancer.RESULTS: We found no significant difference between the cancer and control populations in terms of genotype distribution (CC, CG and GG). In addition, we found no association between the hOGG1 Ser326Cys polymorphism and cancer risk, MSI status, TNM stage or tumor location in colorectal cancer patients.CONCLUSIONS: These results suggest that unlike for other cancer types, the hOGG1 Ser326Cys polymorphism is not a major genetic risk factor for colorectal cancer.J Epidemiol 2007; 17: 156-160.
- 日本疫学会の論文
- 2007-09-01
著者
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Park Hye-rin
Korean Hereditary Tumor Registry Cancer Research Institute And Cancer Research Center Seoul National
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Park Hye-won
Korean Hereditary Tumor Registry Cancer Res. Inst. And Cancer Res. Center Seoul National Univ.
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Park Jae-gahb
韓国
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JEONG Seung-Yong
Research Institute and Hospital, National Cancer Center
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KIM Il-Jin
Korean Hereditary Tumor Registry, Cancer Research Institute and Cancer Research Center, Seoul Nation
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KANG Hio
Korean Hereditary Tumor Registry, Cancer Research Institute and Cancer Research Center, Seoul Nation
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JANG Sang-Geun
Korean Hereditary Tumor Registry, Cancer Research Institute and Cancer Research Center, Seoul Nation
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PARK Jae-Gahb
Korean Hereditary Tumor Registry, Cancer Research Institute and Cancer Research Center, Seoul Nation
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Kang Hio
Korean Hereditary Tumor Registry Cancer Research Institute And Cancer Research Center Seoul National
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Jeong Seung-yong
Research Institute And Hospital National Cancer Center
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Shin Hai-rim
フランス
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LEE Jin
Research Institute for Food Science, Kyoto University
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AHN Sun-A
Korean Hereditary Tumor Registry, Cancer Research Institute and Cancer Research Center, Seoul Nation
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SHIN Hai-Rim
Research Institute and Hospital, National Cancer Center
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Park Jae-gahb
Department Of Surgery Seoul National University College Of Medicine
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Park Jae-hyun
Department Of Physical Education College Of Physical Education Dong-a University
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Ahn Sun-a
Korean Hereditary Tumor Registry Cancer Research Institute And Cancer Research Center Seoul National
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Kim Il-jin
Korean Hereditary Tumor Registry Cancer Research Institute And Cancer Research Center Seoul National
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Lee Jin
Research Institute And Hospital National Cancer Center
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Shin Hai-rim
Research Institute And Hospital National Cancer Center
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