Captopril Attenuates Matrix Metalloproteinase-2 and -9 in Monocrotaline-Induced Right Ventricular Hypertrophy in Rats
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概要
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Little is known about the influence of angiotensin converting enzyme (ACE) inhibitors on matrix metalloproteinase (MMP) in right ventricular remodeling. We investigated the effect of captopril, an ACE inhibitor, on MMP-2 and MMP-9 in monocrotaline-induced right ventricular hypertrophy. Six-week-old male Wistar rats were injected intraperitoneally with monocrotaline (60 mg/kg) or saline. The rats were administrated captopril (30 mg/kg per day) or a vehicle orally for 24 days from the day of monocrotaline injection. At day 25, echocardiography was performed and hearts were excised. Expressions and activities of MMP-2 and MMP-9 were measured by Western blotting and by gelatin zymography, respectively. In monocrotaline-injected rats, right ventricular weight/tail length ratio increased significantly. Histological analysis revealed cardiomyocyte hypertrophy and fibrosis in right ventricular sections. Echocardiography showed right ventricular dysfunction compared with saline-injected rats. The right ventricular hypertrophy, fibrosis, and dysfunction were inhibited by captopril. However, captopril did not attenuate an increase in pulmonary artery pressure. MMP-2 and MMP-9 expressions and activities in right ventricles increased significantly in monocrotaline-injected rats and captopril inhibited them. These findings indicate that captopril attenuates the development of monocrotaline-induced right ventricular hypertrophy in association with inhibition of MMP-2 and MMP-9 in rats.
- 社団法人 日本薬理学会の論文
- 2008-12-20
著者
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Harada Toshiyuki
Laboratory Of Veterinary Pharmacology School Of Veterinary Medicine Kitasato University
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Harada Toshiyuki
北里大学 獣医学部獣医薬理学
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Kikuzuki Ryuta
Laboratory Of Veterinary Pharmacology School Of Veterinary Medicine Kitasato University
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Kikuzuki Ryuta
北里大学 獣医学部獣医薬理学
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Yamawaki Hideyuki
Laboratory of Veterinary Pharmacology, School of Veterinary Medicine, Kitasato University, Japan
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Okada Muneyoshi
Laboratory of Veterinary Pharmacology, School of Veterinary Medicine, Kitasato University, Japan
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Hara Yukio
Laboratory of Veterinary Pharmacology, School of Veterinary Medicine, Kitasato University, Japan
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Yamawaki Hideyuki
東京大学 農生命科研究
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Yamawaki Hideyuki
Department Of Veterinary Pharmacology School Of Veterinary Medicine Kitasato University
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Hori Yasutomo
Laboratory of Small Animal Internal Medicine, School of Veterinary Medicine, Kitasato University
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Hori Yasutomo
Laboratory Of Small Animal Internal Medicine School Of Veterinary Medicine Kitasato University
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Okada Muneyoshi
Department Of Veterinary Pharmacology Graduate School Of Agriculture And Life Sciences The Universit
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Okada Muneyoshi
Department Of Veterinary Pharmacology School Of Veterinary Medicine And Animal Sciences Kitasato Uni
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Okada Muneyoshi
Laboratory Of Veterinary Pharmacology School Of Veterinary Medicine Kitasato University
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Hara Yukio
Laboratory Of Veterinary Pharmacology School Of Veterinary Medicine Kitasato University
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YAMAWAKI Hideyuki
Laboratory of Veterinary Pharmacology, Kitasato University, Towada, Aomori 034–8628, Japan
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