Cell-Cycle-Dependent Pharmacology of Methotrexate in HL-60
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概要
- 論文の詳細を見る
The role of the susceptibility of cells and the pharmacokinetics of MTX on the time-dependent change of methotrexate (MTX) pharmacologic action in HL-60 (human leukemia cell) was investigated from the viewpoints of the rhythm of DNA synthesis. The highest activity of MTX was observed at the time when DNA synthesis, dihydrofolate reductase (DHFR) activity, DHFR content, and DHFR mRNA content increased and the lowest activity was observed at the time when they decreased. There were significant time-dependent changes in MTX efflux. The result corresponded to the rhythm in MTX activity. The present study suggests that the time-dependent change of MTX activity is caused by a change in the sensitivity of cells and the pharmacokinetics of the drug. Therefore, the choice of dosing time associated with cell rhythmicity may help to achieve rational chronotherapeutics, increasing therapeutic effects.
- 社団法人 日本薬理学会の論文
- 2005-12-20
著者
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Koyanagi Satoru
Department of Medico-Pharmaceutical Sciences, Kyushu University
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FUKAGAWA Tatsuo
PREST Jap. Sci. Tec. Corp.(JSP), Natl. Inst. Genet.
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ARAMAKI Hironori
Department of Molecular Biology, Daiichi College of Pharmaceutical Sciences
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OHDO Shigehiro
Pharmaceutics, Division of Clinical Pharmacy, Department of Medico-Pharmaceutical Sciences, Faculty
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Aramaki Hironori
Department Of Microbiology Daiichi College Of Pharmaceutical Sciences:faculty Of Pharmaceutical Scie
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MATSUNAGA Naoya
Pharmaceutics, Division of Clinical Pharmacy, Department of Medico-Pharmaceutical Science, Faculty o
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Ohdo Shigehiro
Pharmaceutics Div. Of Clinical Pharmacy Dep. Of Medico-pharmaceutical Sciences Fac. Of Pharmaceutica
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Ohdo Shigehiro
Pharmaceutics Division Of Clinical Pharmacy Department Of Medico-pharmaceutical Science Faculty Of P
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Ohdo Shigehiro
Department Of Pharmaceutics Division Of Pharmaceutical Science Graduate School Kyushu University
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Koyanagi Satoru
Department Of Pharmaceutics Division Of Pharmaceutical Science Graduate School Kyushu University
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Koyanagi Satoru
Department Of Medico-pharmaceutical Sciences Kyushu University
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Fujioka Toshihiro
National Institute Of Genetics And The Graduate University For Advanced Studies
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Fukagawa Tatsuo
Prest Jap. Sci. Tec. Corp.(jsp) Natl. Inst. Genet.
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Higuchi Shun
Department Of Clinical Pharmacokinetics Graduate School Kyushu University
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YAMAUCHI Atsushi
Pharmaceutics, Division of Clinical Pharmacy, Department of Medico-Pharmaceutical Science, Faculty o
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ICHIMIYA Takanobu
Pharmaceutics, Division of Clinical Pharmacy, Department of Medico-Pharmaceutical Science, Faculty o
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INOUE Kouichi
Pharmaceutics, Division of Clinical Pharmacy, Department of Medico-Pharmaceutical Science, Faculty o
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TAGUCHI Yukie
Pharmaceutics, Division of Clinical Pharmacy, Department of Medico-Pharmaceutical Science, Faculty o
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HIGUCHI Shun
Pharmaceutics, Division of Clinical Pharmacy, Department of Medico-Pharmaceutical Science, Faculty o
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Taguchi Yukie
Pharmaceutics Division Of Clinical Pharmacy Department Of Medico-pharmaceutical Science Faculty Of P
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Koyanagi Satoru
Pharmaceutics Division Of Clinical Pharmacy Department Of Medico-pharmaceutical Science Faculty Of P
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Matsunaga Naoya
Department Of Pharmaceutics Graduate School Of Pharmaceutical Sciences Kyushu University
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Ichimiya Takanobu
Pharmaceutics Division Of Clinical Pharmacy Department Of Medico-pharmaceutical Science Faculty Of P
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Inoue K
Pharmaceutics Division Of Clinical Pharmacy Department Of Medico-pharmaceutical Science Faculty Of P
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Yamauchi Atsushi
Pharmaceutics Division Of Clinical Pharmacy Department Of Medico-pharmaceutical Science Faculty Of P
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Koyanagi Satoru
Department of Biochemistry, Faculty of Pharmaceutical Sciences, Fukuoka University
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