ラットを用いた実験的肩関節拘縮モデルの確立

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Shoulder contracture is caused by various pathologies, little is known about its etiology and pathophysiology. Numbers of studies of the contracture have been performed using the knee joint, but little has been investigated using the shoulder joint. The purpose of the study was to establish the contracture model using rats and to clarify the pathogenesis. 24 Sprague-Dawley rats were used. 12 underwent extraarticular glenohumeral joint immobilization using internal fixation (immobilization group). Another 12 underwent screw insertion into the humerus (Sham group). Rats were euthanized either 8 or 16 weeks after surgery. The range of motion (ROM) of the glenohumeral joint was measured repeatedly under 10 gram-loading conditions after the following order: A) removal of the shoulder girdle from the trunk B) removal of the outer muscles other than cuff muscles C) removal of all the cuff muscles, preserving the capsule D) anteroinferior capsulotomy E) anterosuperior capsulotomy F) posteroinferior capsulotomy. Abduction angle and total rotation angle were analyzed.In both 8 weeks and 16 weeks immobilization group, the angle decreased significantly compared to sham group. The abduction angle in the immobilization groups gradually increased after serial capsulotomy. However, the difference in the angle between the immobilization and sham groups remained statistically significant even after an anterior capsulotomy. In the total rotation angle, there was the same trend: After capsulotomy, the angle increased in immobilization group gradually, however, the difference between the 2 groups still remained. In the immobilization groups, there was not significant difference between the abduction angles after removal from the trunk, after skin removal and muscles other than cuff, and removal of all muscles. After anteroinferior and anterosuperior capsulotomy, the difference of the angle became significant. From these results, we concluded that the capsule may play an important role in the pathogenesis of the contracture.
2009-07-27

ラットを用いた実験的肩関節拘縮モデルの確立

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