Expression of OATP1B3 determines uptake of Gd-EOB-DTPA in hepatocellular carcinoma
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概要
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Background: Gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid (Gd-EOB-DTPA) is an MRI contrast agent with perfusion and hepatoselective properties. The purpose of the study was to examine uptake of Gd-EOB-DTPA in the hepatobiliary phase in hepatocellular carcinoma (HCC). Methods: A retrospective analysis of 22 patients with HCC who underwent preoperative Gd-EOB-DTPA-enhanced MRI was performed. Enhancement ratios (ERs) and expression levels of the organic anion transporter (OATP) 1B3 protein were examined. Results: Gd-EOB-DTPA accumulated in the hepatobiliary phase in 6 of the 22 cases. All 6 Gd-EOB-DTPA-positive cases were moderately differentiated HCC, but 11 other moderately differentiated HCCs did not show Gd-EOB-DTPA uptake. Histopathologically, 4 Gd-EOB-DTPA-positive HCCs and 5 Gd-EOB-DTPA-negative HCCs produced bile. HCCs with Gd-EOB-DTPA uptake overexpressed OATP1B3 compared with HCCs without Gd-EOB-DTPA uptake, and OATP1B3 levels were significantly correlated with ERs (r = 0.91, P < 0.0001). Conclusions: Uptake of Gd-EOB-DTPA in HCC is determined by expression of OATP1B3 rather than by tumor differentiation or bile production.
- 2009-07-01
著者
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NITTA TAKASHI
Department of Surgery, Cardiovascular Surgery, Nippon Medical School
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UEMOTO Shinji
Department of Surgery, Graduate School of Medicine, Kyoto University
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IKAI Iwao
Department of Surgery, Kyoto Medical Center
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Uemoto Shinji
Division Of Hepato-biliary-pancreatic Surgery And Transplantation Department Of Surgery Kyoto Univer
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ISODA Hiroyoshi
Department of Radiology, Fujieda Municipal Hospital
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Ida Hiroshi
Department Of Gastroenterology And Hepatology Kyoto University Graduate School Of Medicine
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KITAMURA Koji
Department of Urology, Saiseikai Kyoto Hospital
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NARITA MASATO
Department of Surgery, Graduate School of Medicine, Kyoto University
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HATANO ETSURO
Department of Surgery, Graduate School of Medicine, Kyoto University
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TAURA KOJIRO
Department of Gastroenterological Surgery, Kyoto University Graduate School of Medicine
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Miyagawa Hayashino
Department Of Diagnostic Pathology Kyoto University Hospital
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Nitta Takashi
Department Of Surgery Graduate School Of Medicine Kyoto University
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Taura Kojiro
Department Of Surgery Graduate School Of Medicine Kyoto University
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Kitamura Koji
Department Of Surgery Graduate School Of Medicine Kyoto University
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Hatano Etsuro
Department Of Surgery Graduate School Of Medicine Kyoto University
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Hatano Etsuro
Departments Of Hepato-biliary-pancreatic Surgery And Transplantation Kyoto University
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Narita Masato
Department Of Surgery Graduate School Of Medicine Kyoto University
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Isoda Hiroyoshi
Department Of Diagnostic Imaging And Nuclear Medicine Graduate School Of Medicine Kyoto University
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ARIZONO Shigeki
Department of Diagnostic Imaging and Nuclear Medicine, Graduate School of Medicine, Kyoto University
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YASUCHIKA Kentaro
Department of Surgery, Graduate School of Medicine, Kyoto University
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Arizono Shigeki
Department Of Diagnostic Imaging And Nuclear Medicine Graduate School Of Medicine Kyoto University
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Uemoto Shinji
Department Of Hepato-biliary-pancreatic Surgery And Transplantation Kyoto University
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Arizono Shigeki
Department Of Diagnostic Imaging And Nuclear Medicine Graduate School Of Medicine
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Ikai Iwao
Department Of Surgery Graduate School Of Medicine Kyoto University
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Ikai Iwao
Department Of Gastroenterological Surgery Graduate School Of Medicine Kyoto University
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Yasuchika Kentaro
Department Of Surgery Graduate School Of Medicine Kyoto University
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Nitta Takashi
Department Of Biological Regulation And Regenerative Surgery Nippon Medical School Graduate School O
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Isoda Hiroyoshi
Department Of Diagnostic Imaging And Nuclear Medicine Graduate School Of Medicine
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Ikai Iwao
Department Of Gastroenterological Surgery Kyoto University Graduate School Of Medicine
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Hatano Etsuro
Department Of Surgery Kyoto University Graduate School Of Medicine
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Miyagawa-Hayashino Aya
Department of Diagnostic Pathology, Kyoto University Hospital
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HATANO Etsuro
Department of Surgery, Graduate School of Medicine Kyoto University
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TAURA Kojiro
Department of Surgery, Graduate School of Medicine Kyoto University
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KITAMURA Koji
Department of Rural Technologies, National Institute for Rural Engineering, National Agriculture and Food Research Organization
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