The genome size evolution of medaka (Oryzias latipes) and fugu (Takifugu rubripes)

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概要

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• Evolution of the genome size in eukaryotes is often affected by changes in the noncoding sequences, for which insertions and deletions (indels) of small nucleotide sequences and amplification of repetitive elements are considered responsible. In this study, we compared the genomic DNA sequences of two kinds of fish, medaka (Oryzias latipes) and fugu (Takifugu rubripes), which show two-fold difference in the genome size (800 Mb vs. 400 Mb). We selected a contiguous DNA sequence of 790 kb from the medaka chromosome LG22 (linkage group 22), and made a precise comparison with the sequence (387 kb) of the corresponding region of Takifugu. The sequence of 178 kb in total was aligned common between two fishes, and the remaining sequences (612 kb for medaka and 209 kb for fugu) were found abundant in various repetitive elements including many types of unclassified low copy repeats, all of which accounted for more than a half (54%) of the genome size difference. Furthermore, we identified a significant difference in the length ratio of the unaligned sequences that locate between the aligned sequences (USBAS), particularly after eliminating known repetitive elements. These USBAS with no repetitive elements (USBAS-nr) located within the intron and intergenic region. These results strongly indicated that amplification of repetitive elements and compilation of indels are major driving forces to facilitate changes in the genome size.

• 日本遺伝学会の論文
• 2007-04-25

著者

• Sasaki Takashi

  Department of Cardiothoracic Surgery, Nippon Medical School

• Asakawa Shuichi

  Department of Aquatic Biosciences, Graduate School of Agricultural and Life Sciences, The University

• 清水 信義

  慶応大・先導研gspセ

• SHIMIZU Atsushi

  Department of Transplant Surgery, Jichi Medical University

• Asakawa Shuichi

  Department Of Molecular Biology Keio University School Of Medicine

• Asakawa Shuichi

  慶応義塾大学 医学部分子生物学

• Asakawa Shuichi

  Department Of Aquatic Biosciences Graduate School Of Agricultural And Life Sciences The University O

• Shimizu Nobuyoshi

  Department of Molecular Biology, School of Medicine, Keio University

• Hori Hiroshi

  Division of Biological Science, Graduate School of Science, Nagoya University

• Imai Shuichiro

  Division Of Biological Science Graduate School Of Science Nagoya University

• Asakawa Syuichi

  Department Of Molecular Biology Keio University School Of Medicine

• Shima Akihiro

  Department Of Molecular Biology Keio University School Of Medicine

• Shiohama Aiko

  慶応義塾大学 医学部分子生物学

• Shimada A

  Department Of Molecular Biology Keio University School Of Medicine

• Shima A

  Department Of Molecular Biology Keio University School Of Medicine

• Sasaki Takashi

  Department Of Bioregulation. Institute For Medical Genetics Kumamoto University Medical School

• Asakawa S

  Dep. Of Aquatic Biosciences Graduate School Of Agricultural And Life Sciences The Univ. Of Tokyo 1-1

• Hori Hiroshi

  Department Of Applied Biological Chemistry Tamagawa University

• Hori Hiroshi

  Division Of Biological Science Graduate School Of Science Nagoya University

• Shimizu N

  Keio Univ. School Of Medicine Tokyo Jpn

• Shimizu N

  Department Of Molecular Biology Keio University School Of Medicine

• Shimizu Nobuyoshi

  Advanced Research Center For Genome Super Power Keio University

• Shimizu Nobuyoshi

  Department Of Molecular Biology School Of Medicine Keio University

• Shimizu Nobuyoshi

  Department Of Cancer And Thoracic Surgery Okayama University Graduate School Of Medicine

• Hori Hidemasa

  Division Of Biological Science Graduate School Of Science Nagoya University

• Higuchi Hiroko

  Biotechnology Research Center Toyama Prefectural University

• Shima Akihiro

  Lab. Radiat. Biol. Dept. Biol. Sci. Grad. Sch. Sci. Univ. Tokyo.

• Shimada Atsuko

  Department Of Biological Sciences University Of Tokyo

• Shibata N

  Advanced Research Center For Genome Super Power Keio University

• Shima Akihiro

  Department Of Integrated Biosciences University Of Tokyo

• 清水 信義

  Department Of Biology Faculty Of Science Shinshu University

• Suzuki Norio

  Department Of Biological Sciences Graduate School Of Science Hokkaido University

• Shimada Atsuko

  Department Of Molecular Biology Keio University School Of Medicine

• Shimizu Atsushi

  Department Of Molecular Biology Keio University School Of Medicine

• Shimizu Atsushi

  Department Of Dermatology Keio University School Of Medicine

• Hori Hiroshi

  Division Of Bioengineering Graduate School Of Engineering Science Osaka University

• Shimizu Atsushi

  Department Of Chemistry College Of Science And Engineering Aoyama Gakuin University

• Sasaki Takashi

  Department Of Molecular Biology Keio University School Of Medicine

• Asakawa Shuichi

  Department Of Aquatic Bioscience Graduate School Of Agricultural And Life Sciences The University Of

• Sasaki Takashi

  Department Of Applied Biological Chemistry Graduate School Of Agricultural And Life Sciences The Uni

• Shimizu Nobuyoshi

  Department Of Cancer And Thoracic Surgery Okayama University Graduate School Of Medicine And Dentist

• Shiohama Aiko

  Department Of Molecular Biology Keio University School Of Medicine

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