アミノ酸デンドリマーを用いた核酸デリバリー
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概要
- 論文の詳細を見る
デンドリティックポリリジンはアミノ酸から構成されるデンドリマーで，プラスミドDNAと中性の複合体を形成し，さまざまな培養細胞に対して，低毒性で高いトランスフェクション効率を示す．リニアタイプのポリリジンとくらべ，細胞内に取り込まれる量は少ないが，細胞質への移行効率が高く，また，DNAのコンパクションが弱い．細胞内でDNAをリリースしやすい，あるいは，転写因子がアクセスしやすいことが高発現の原因だろう．プラスミドDNAとの複合体を尾静脈より投与すると，3時間後においても分解されていないDNAが血中から観察され，その他，肝臓や肺にも分布がみられた．さらに，siRNAの肝臓へのデリバリーにも成功し，そのin vivoでの応用が期待される．
- 日本DDS学会の論文
- 2007-03-10
著者
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新留 琢郎
九州大学大学院工学研究院
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新留 康郎
九州大学大学院工学研究院応用化学部門
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新留 康郎
九州大学大学院 工学研究院応用化学部門
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新留 琢郎
長崎大学 院 生産科学
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新留 康郎
九大 大学院工学研究院
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新留 康郎
九大院工
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新留 康郎
九州大学大学院工学研究科
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河野 喬仁
九州大学大学院工学研究院応用化学部門
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山形 真人
九州大学大学院工学研究院応用化学部門
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栗原 亮介
九州大学大学院工学研究院応用化学部門
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奥田 竜也
九州大学先導物質科学研究所
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Niidome Takuro
Graduate School Of Science And Technology Nagasaki University
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Niidome T
Department Of Applied Chemistry Faculty Of Engineering Nagasaki University
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新留 琢郎
九州大学大学院 工学研究院応用化学部門
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Nishio T
Department Of Chemistry Faculty Of Science Kyushu University
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Niidome Yasuro
Department Of Applied Chemistry Faculty Of Engineering Kyushu University
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Niidome Yasuro
Dep. Of Applied Chemistry Graduate School Of Engineering Kyushu Univ.
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