Expression of DMRT Genes in the Gonads of Rana rugosa During Sex Determination
スポンサーリンク
概要
- 論文の詳細を見る
Sex is determined by various transcription factors. Dmrt1, a gene that contains the DM domain (Doublesex/Mab-3 DNA-binding motif), is known to be one of the critical factors required for testicular development in vertebrates. Recently, other DM domain-containing genes (DMRT genes) were isolated in mice and fish. In mice, three of the seven known DMRT genes are expressed in the embryonic gonad. In amphibians, however, only Dmrt1 and Dmrt4 have been cloned. To clarify the role(s) of DMRT genes in sex determination in vertebrates, the molecular cloning of amphibian DMRT genes would be very helpful. In this study, we isolated Dmrt2, -3, and -5 from the frog Rana rugosa and analyzed by RT-PCR their expression during sex determination. The analysis revealed that all three genes are expressed in the developing gonad/mesonephros complex during sex determination with no dimorphism. The results suggest that Dmrt2, -3, and -5 may be involved in sexual development in R. rugosa and that they may function in both testicular and ovarian differentiation.
- 社団法人 日本動物学会の論文
- 2007-01-25
著者
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NAKAMURA Masahisa
Department of Biology, Faculty of Education and Integrated Arts and Sciences, Waseda University
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Oshima Yuki
Department of Biology, Faculty of Education and Integrated Arts and Sciences, Waseda University
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Nakamura Masahisa
Department Of Biology Faculty If Education And Integrated Arts And Sciences Waseda University
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Oshima Yuki
Department Of Biology Faculty Of Education And Integrated Arts And Sciences Waseda University
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MATSUSHITA Yusaku
Department of Biology, Faculty of Education and Integrated Arts and Sciences, Waseda University
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Matsushita Yusaku
Department Of Biology Faculty Of Education And Integrated Arts And Sciences Waseda University
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Oshima Yuki
Department of Applied Quantum Physics and Nuclear Engineering, Kyushu University, Fukuoka 819-0395, Japan
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