A Mucus Adhesion Promoting Protein, MapA, Mediates the Adhesion of Lactobacillus reuteri to Caco-2 Human Intestinal Epithelial Cells
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概要
- 論文の詳細を見る
Lactobacillus reuteri is one of the dominant lactobacilli found in the gastrointestinal tract of various animals. A surface protein of L. reuteri 104R, mucus adhesion promoting protein (MapA), is considered to be an adhesion factor of this strain. We investigated the relation between MapA and adhesion of L. reuteri to human intestinal (Caco-2) cells. Quantitative analysis of the adhesion of L. reuteri strains to Caco-2 cells showed that various L. reuteri strains bind not only to mucus but also to intestinal epithelial cells. In addition, purified MapA bound to Caco-2 cells, and this binding inhibited the adhesion of L. reuteri in a concentration-dependent manner. Based on these observations, the adhesion of L. reuteri appears due to the binding of MapA to receptor-like molecules on Caco-2 cells. Further, far-western analysis indicated the existence of multiple receptor-like molecules in Caco-2 cells.
- 社団法人 日本農芸化学会の論文
- 2006-07-23
著者
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SATOH Eiichi
Department of Applied Biology and Chemistry, Faculty of Applied Bio-Science, Tokyo University of Agr
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UCHIMURA Tai
Department of Applied Biology and Chemistry, Faculty of Applied Bio-Science, Tokyo University of Agr
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OKADA Sanae
Department of Applied Biology and Chemistry, Faculty of Applied Bio-Science, Tokyo University of Agr
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Uchimura Tai
Department Of Agricultural Chemistry Tokyo University Of Agriculture
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Uchimura Tai
Dep. Of Applied Biology And Chemistry Fac. Of Applied Bio-science Tokyo Univ. Of Agriculture
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Okada Sanae
Dep. Of Applied Biology And Chemistry Fac. Of Applied Bio-science Tokyo Univ. Of Agriculture
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Satoh Eiichi
Dep. Of Applied Biology And Chemistry Fac. Of Applied Bio-science Tokyo Univ. Of Agriculture
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Okada Sanae
Department Of Applied Biology And Chemistry Tokyo University Of Agriculture
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MIYOSHI Yukihiro
Department of Applied Biology and Chemistry, Tokyo University of Agriculture
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Miyoshi Yukihiro
Department Of Applied Biology And Chemistry Tokyo University Of Agriculture
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Satoh Eiichi
Department Of Applied Biology And Chemistry Faculty Of Applied Bio-science Tokyo University Of Agric
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