複数回膜貫通型膜タンパク質の立体構造形成機構 : バンド3タンパク質研究の成果より

概要

論文の詳細を見る
The conventional view of biosynthesis of membrane-embedded regions of integral membrane proteins is that the topology of membrane proteins is determined by signal-anchor sequences and signal-anchor sequence of type II. Here, we briefly review the evidence that in the case of integral membrane proteins with many membrane spans, and that the topology of membrane proteins is determined not only by signal-anchor sequences and signal-anchor sequence of type II, but also by signal-anchor sequence of type I. Evidence from band 3 study indicates that hydrophobic membrane peptide portions are not necessarily in contact with lipids in the membrane lipid bilayer and that even hydrophilic peptide portions are integrated into the lipid bilyar by the action of signal-anchor sequence of type I.
日本生物物理学会の論文
2006-01-25