The Preparation and Evaluation of 1-Substituted 1,2,3,4-Tetrahydro- and 3,4-Dihydro-β-carboline Derivatives as Potential Antitumor Agents

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概要

• 論文の詳細を見る

• A series of 1-substituted 1,2,3,4-tetrahydro- and 3, 4-dihydro-β-carboline derivatives have been synthesized and evaluated for antitumor activity against murine P-388 and human tumor cell lines, KB-16, A-549 and HT-29. All of the compounds prepared, except for 19, showed significant cytotoxicity. Among them, compound 29 exhibited the most potent activity against all tested tumor cell lines. There was an apparent lack of correlation regarding cytotoxicity between 1,2,3,4-tetrahydro- and 3,4-dihydro-β-carbolines. This study is the first to discover compound 29 as a potential lead for the development of future anticancer agents. The mode of inhibition for compound 29 was proposed.

• 公益社団法人日本薬学会の論文
• 2005-01-01

著者

• SHEN Ya-Ching

  Institute of Marine Resources, National Sun Yat-sen University

• CHEN Ching-Yeu

  Institute of Marine Resources, National Sun Yat-sen University

• HSIEH Pei-Wen

  Graduate Institute of Natural Products, Chang Gung University

• Hsieh Pei

  Graduate Institute Of Natural Products Chang Gung University

• Hsieh P‐w

  Institute Of Marine Resources National Sun Yat-sen University

• Chen C‐y

  National Sun Yat‐sen Univ. Kaohsiung Twn

• Duh Chang-yih

  Dep. Of Marine Biotechnology And Resources National Sun Yat-sen Univ.

• Duh Chang-yih

  Institute Of Marine Resources National Sun Yat-sen University

• Shen Ya-ching

  Institute Of Marine Resources National Sun Yat-sen University

• Chen Ching-yeu

  Institute Of Marine Resources National Sun Yat-sen University

• HSIEH Pei-Wen

  Institute of Marine Resources, National Sun Yat-sen University

• LIN Yat-Min

  Institute of Marine Resources, National Sun Yat-sen University

• KO Chin-Lien

  Institute of Marine Resources, National Sun Yat-sen University

• Lin Yat-min

  Institute Of Marine Resources National Sun Yat-sen University

• Ko Chin-lien

  Institute Of Marine Resources National Sun Yat-sen University

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