Molecular Mechanisms and Drug Development in Aquaporin Water Channel Diseases : The Translocation of Aquaporin-5 From Lipid Rafts to the Apical Plasma Membranes of Parotid Glands of Normal Rats and the Impairment of It in Diabetic or Aged Rats
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概要
- 論文の詳細を見る
Salivary secretion from rat salivary glands occurs in response to stimulation by acetylcholine and norepinephrine released from nerve endings. Aquaporin-5 (AQP5) localizes in lipid rafts under control conditions and is induced to traffic to the apical plasma membrane in interlobular ducts of rat parotid glands by the activation of M3 muscarinic acetylcholine receptors or α1-adrenoceptors. This review will focus on the mechanisms of the translocation of AQP5 from lipid rafts to the apical plasma membrane in the interlobular duct cells of parotid glands of normal rats and the impairment of its translocation in diabetic or senescent rats.
- 社団法人 日本薬理学会の論文
- 2004-11-20
著者
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Inoue Noriko
Department Of Cardiology Yokohama City University Hospital
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Ishikawa Yasuko
Department Of Medical Pharmacology Institute Of Health Biosciences University Of Tokushima Graduate
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Nakae Y
Departments Of Internal Medicine Ii Nagoya University School Of Medicine
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Nakae Yoshiko
Department Of Oral And Maxillofacial Anatomy Institute Of Health Biosciences University Of Tokushima
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Nakae Yoshiko
Department Of First Oral Anatomy School Of Dentistry Tokushima University
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Ishikawa Yasuko
Department Of Medical Pharmacology Institute Of Health Biosciences The University Of Tokushima Gradu
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YUAN Zhenfang
Department of Internal Medicine, Peking University First Hospital
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Yuan Zhenfang
Dep. Of Internal Medicine Peking Univ. First Hospital Chn
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Yuan Zhenfang
Department Of Internal Medicine Peking University First Hospital
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Inoue Noriko
Department Of Medical Pharmacology Institute Of Health Biosciences University Of Tokushima Graduate
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