Reverse Perfusion-Metabolism Mismatch Predicts Good Prognosis in Patients Undergoing Cardiac Resynchronization Therapy : A Pilot Study
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概要
- 論文の詳細を見る
Background Cardiac resynchronization therapy (CRT) improves glucose metabolism in the septum of patients with heart failure, so in the present study the predictive value of combined fluorodeoxyglucose (FDG)-positron emission tomography (PET) and metoxy-isobutyl isonitrile (MIBI)-single photon emission computed tomography (SPECT) for the prognosis of patients undergoing CRT was investigated. Methods and Results Fourteen patients (70.3±8.2 years) who underwent FDG-PET and MIBI-SPECT before implantation of a biventricular pacemaker were enrolled. The total number of matches, mismatches, reverse mismatches, summed difference score (SDS: sum total of FDG-MIBI scores) and SDS per segment (%SDS) in each of 5 areas of myocardium (septum, anterior, lateral, inferior area, apex) was calculated and compared between the survival groups (all survival: survival group; survival without ischemic heart disease (IHD): non-IHD survival group) and non-survival group. Both the number of reverse mismatch segments and the %SDS in the septum in the non-IHD survival group were significantly greater than in the non-survival group (3.2±1.6 vs 0.5±0.6, p<0.05; 0.62±0.61 vs -0.11±0.19, p<0.05). The receiver-operating characteristics curves for prognosis showed that the area under the curve for the number of reverse mismatch segments in the septum (0.93; confidence interval 0.61-0.98) was significantly greater. Conclusion A reverse mismatch pattern in the septum can predict a good prognosis for patients treated with CRT.
- 社団法人日本循環器学会の論文
- 2006-12-20
著者
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Umemura Satoshi
Department of medical science and cardiorenal medcine, Yokohama City University Graduate School of M
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Uchino Kazuaki
Department of Cardiorenal Medicine, Yokohama City University Graduate School of Medicien
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Kimura Kazuo
Department of Cardiorenal Medicine, Yokohama City University Graduate School of Medicien
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ISHIKAWA Toshiyuki
Department of Medical Science and Cardiorenal Medicine, Yokohama City University School of Medicine
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SUMITA Shinichi
Division of Cardiology, Yokohama City University Medical Center
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MATSUSHITA Kohei
Department of Medical Science and Cardiorenal Medicine, Yokohama City University School of Medicine
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MATSUMOTO Katsumi
Department of Medical Science and Cardiorenal Medicine, Yokohama City University School of Medicine
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SUMITA Shinichi
Department of Medical Science and Cardiorenal Medicine, Yokohama City University School of Medicine
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Inoue Noriko
Department of Medical Science and Cardiorenal Medicine, Yokohama City University School of Medicine
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Kobayashi Tsukasa
Department of Medical Science and Cardiorenal Medicine, Yokohama City University School of Medicine
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Taima Minoru
Department of Medical Science and Cardiorenal Medicine, Yokohama City University School of Medicine
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Uchino Kazuaki
Division Of Cardiology Yokohama City University Medical Center
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Uchino Kazuaki
横浜市立大学附属市民総合医療センター 心臓血管センター
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Masuda Shin-ichiro
横浜市立大学 医学研究科第二内科学
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Nakati Tatsuya
横浜市立大学附属市民総合医療センター 心臓血管センター
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Matsushita Kohei
Department Of Cardiovascular Surgery Yokohama City University Medical Center
-
Ishikawa T
Department Of Medical Science And Cardiorenal Medicine Yokohama City University Graduate School Of M
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Sumita S
Division Of Cardiology Yokohama City University Medical Center
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Sumita Shinichi
横浜市立大学附属市民総合医療センター 心臓血管センター
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Sumita Shinichi
Yokohama City University School Of Medicine Cardiovascular Center
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Sumita Shinichi
Second Department Of Internal Medicine Yokohama City University Hospital
-
Ishigami T
Department Of Second Internal Medicine Yokohama City University School Of Medicine
-
Taima Minoru
Department Of Cardiology Yokohama City University Hospital
-
Inoue Noriko
Department Of Cardiology Yokohama City University Hospital
-
Kobayashi Tsukasa
横浜市立大学 医学研究科内科学循環器内科
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Kobayashi Tsukasa
Department Of Medical Science And Cardiorenal Medicine Yokohama City University Graduate School Of M
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Uchida Keiji
横浜市立大学附属市民総合医療センター 心臓血管センター
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Uchino Kazuaki
Department Of Medical Science And Cardiorenal Medicine Yokohama City University Graduate School Of M
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Minami Kazutoshi
Yokohama City University Medical Center
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Matsumoto Katsumi
Department Of Medical Science And Cardiorenal Medicine Yokohama City University School Of Medicine
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Inoue Tomio
Department Of Radiology Yokohama City University School Of Medicine
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Inoue Tomio
Department Of Radiology Graduate School Of Medicine Yokohama City University
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Kohagura Kentaro
琉球大学 第三内科
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Masuda Shin-ichiro
横浜市立大学 医学系研究科病態制御内科学
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Uchino Kazuaki
Department Of Cardiology Sagamihara National Hospital
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Nakachi Tatsuya
横浜市立大学 心臓血管セ
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Takahashi Nobukazu
Department of Radiology, Yokohama City University Graduate School of Medicine
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Shimura Miei
Department of Medical Science and Cardiorenal Medicine
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Matsumoto K
Department Of Medical Science And Cardiorenal Medicine Yokohama City University School Of Medicine
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Nagura Toshihiro
Division Of Cardiology Kanagawa Cardiovascular And Respiratory Center
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Takahashi N
Department Of Pediatric Cardiology Yokohama City University School Of Medicine
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Matsumoto Katsumi
Department Of Geology And Geophysics University Of Minnesota
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Takahashi Nobukazu
Department Of Radiology Graduate School Of Medicine Yokohama City University
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Nakagawa Takeshi
Department Of Radiology Yokohama City University School Of Medicine
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Takahashi Nobukazu
Department Of Radiology Yokohama City University School Of Medicine
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Uchida Keiji
First Department Of Surgery Yokohama City University School Of Medicine
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Takahashi Nobukazu
Department Of Pediatric Cardiology Yokohama City University School Of Medicine
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Ishikawa Toshiyuki
Department Of Cardiology Yokohama City University Hospital
-
Inoue Tomio
Department Of Radiology Yokohama City University Hospital Graduate School Of Medicine
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Kikuchi Miyako
Yokohama City University School Of Medicine Cardiovascular Center
-
Nishizawa Takashi
Department Of Pediatrics Yokohama City University Medical Center
-
Minamizawa Kousuke
Second Department Of Internal Medicine Yokohama City University School Of Medicine
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Suzuki Shinichi
横浜市立大学 医学部心臓血管外科
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Umemura Satoshi
Department Of Internal Medicine Ii Yokohama City University School Of Medicine
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Inoue Tomio
Department Of Physics Kyushu University
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Inoue Tomio
Department Of Cardiology Kanto-teishin Hospital
-
Kimura Kazuo
Department Of Cardiology Other Hospitals
-
Matsumoto Katsumi
Department Of Cardiology Yokohama City University Hospital
-
Shimura Miei
Department of Medical Science and Cardio-Renal Medicine, Yokohama City University Graduate School of Medicine
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Kimura Kazuo
Department of Applied Chemistry, Faculty of Engineering, Osaka University
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- PJ-257 Clinical Characteristics and Prognosis of Patients with Acute Myocardial Infarction due to Left Main Coronary Artery Disease(PJ043,ACS/AMI (Clinical/Treatment) 2 (IHD),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Cir
- PJ-247 Early, Simple, Noninvasive Predictors of Left Main or 3-Vessel Disease in Patients with Non-ST-segment Elevation Acute Coronary Syndromes(PJ042,ACS/AMI (Clinical/Diagnosis) 1 (IHD),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The
- PJ-230 Medial Annular E/e' has a Strongest Relationship with Plasma BNP among Echocardiographical Parameters after a First ST-Elevation AMI(PJ039,Cardiac Function (Clinical) 2 (M),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanes
- PE-569 Different Influence of Insulin Resistance and Low Density Lipoprotein Cholesterol on the Tissue Components of Culprit and Non-Culprit Plaques(PE095,Atherosclerosis (Clinical/Pathophysiology) (IHD),Poster Session (English),The 73rd Annual Scientific
- PE-148 Platelet Reactivity to Dual Antiplatelet Therapy in Patients with Drug Eluting Stent(PE025,Thromboembolism/Antithrombotic Therapy/Thrombolysis 2 (IHD),Poster Session (English),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- OJ-131 Statin Pretreatment Prevents Contrast-Induced Nephopathy in Patients with Acute Myocardial Infarction(OJ22,ACS/AMI (Clinical/Pathophysiology) (IHD),Oral Presentation (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- OE-005 Impact of Long-term Statin Pretreatment on the Incidence of Plaque Rupture and Infarct Size in ST-elevation Acute Myocardial Infarction(OE01,Cardiovascular Pharmacology (Clinical) (H),Oral Presentation (English),The 73rd Annual Scientific Meeting o
- PJ-865 Differences in Clinical Courses Between Massive Pulmonary Embolism and Acute Myocardial Infarction Requiring Percutaneous Cardiopulmonary Life Support(Emergency care / CPR(05)(H),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Ja
- OE-254 Overexpression of ATRAP(AT1 receptor-assosiated protein) in cardiomyocytes completely inhibits cardiac hypertrophy induced by Angiotensin(Cardiac hypertrophy, basic/clinical(01)(M),Oral Presentation(English),The 72nd Annual Scientific Meeting of th