肺とアクアポリン

概要

論文の詳細を見る
The aquaporins (water channels) are novel molecular watertransporters that permit water to across the epithelial and endothelial plasma membrane. Several recent studies strongly suggest that important roles of aquaporins in different pathological situations. This review evaluates the manifestations that aquaporin like water channels contributes fluid transport at distal airway and lung. AQP1expresses in microvascular endothelia, AQP3and AQP4expresses at vasolateral side of large and small airways. AQP5is mainly at alveolar type I cell. Novel developed biophysical and physiological methodologies enable to evaluate active and passive water transport in lung. Transgenic mice lacking aquaporin receptormake it possible to estimate a physiological role of aquaporins in each pathophysiological conditions. Aquaporins make an important contribution in water permeability in lung, despite thereis little contribution in active ion and water transport in the distal lung. Further study of aquaporin should provide new insights into normal and pathological mechanisms of airway and lungfunction.
2000-12-01