Surface Morphology Change of Polylactide Microspheres Enclosing Irinotecan Hydrochloride and Its Effect on Release Properties
スポンサーリンク
概要
- 論文の詳細を見る
We investigated the effect of the polymer-drug interaction on the surface morphology of polymer microspheres and in vitro release properties. Polylactide microspheres enclosing the antitumor agent Irinotecan hydrochloride (CPT) were prepared by the solvent evaporation method of the O/O emulsion system in order to control the concentration of drugs in living organisms. The mean diameter of the polylactide microspheres was kept at approximately 50 μm while varying the content of CPT. The enclosing efficiencies in all runs were around 80%, independent of the CPT content. The surface morphology of polylactide microspheres was significantly affected by the content of the enclosing CPT. Furthermore, the degree of unevenness of the surface was increased with an increase in the CPT content in polylactide microspheres. DSC studies have suggested that the glass transition temperature of polylactide microspheres enclosing CPT shifted to lower temperatures with an increasing CPT content. It was assumed from DSC measurements that the morphological change of polylactide microspheres was induced by a polymer-drug interaction. In vitro release experiments suggested that the release rate in the early period increased with an increasing CPT content. From this study, it was pointed out that the drug, miscible with the matrix polymer, induced a change in surface morphology, providing a significant effect on release properties.
- 社団法人 化学工学会の論文
- 2003-10-01
著者
-
Natsugoe Shoji
First Dept. Of Surgery, Kagoshima University, School of medicine
-
Natsugoe Shoji
First Department Of Surgery Kagoshima University School Of Medicine
-
吉澤 秀和
岡山大学 環境理工学部 物質環境科学科
-
AIKO TAKASHI
First Department of Surgery, Kagoshima University School of Medicine
-
YOSHIZAWA HIDEKAZU
Department of Environmental Chemistry and Materials, Faculty of Environmental Science and Technology
-
NISHINO SATORU
Department of Environmental Chemistry and Materials, Faculty of Environmental Science and Technology
-
KITAMURA YOSHIRO
Department of Environmental Chemistry and Materials, Faculty of Environmental Science and Technology
-
Aiko Takashi
First Department Of Surgery Kagoshima University School Of Medicine
-
Nishino Satoru
Department Of Environmental Chemistry And Materials Faculty Of Environmental Science And Technology
-
Aiko Takashi
First Department Of Surgery Faculty Of Medicine Kagoshima University
-
Yoshizawa Hidekazu
Department Of Environmental Chemistry And Materials Okayama University
-
Kitamura Yoshiro
Department Of Environmental Chemistry And Materials Faculty Of Environmental Science And Technology
-
Yoshizawa Hidekazu
Department of Applied Chemistry and Chemical Engineering, Faculty of Engineering, Kagoshima University
関連論文
- 相分離法による架橋尿素樹脂マイクロカプセル膜の形成機構に関する研究
- Immunohistochemical Detection of the Cytoskeletal Components in Gastric Parietal Cells
- Value of magnetic resonance cholangiopancreatography with secretin stimulation in the evaluation of pancreatic exocrine function after pancreaticogastrostomy
- A case of leptomeningeal carcinomatosis from esophageal basaloid carcinoma diagnosed by quantitative reverse transcription-polymerase chain reaction for carcinoembryonic antigen
- I1-1 The Incidence and Prediction of Micrometastasis In The Cervical Lymph Nodes In Esophageal Sqamous Cell Carcinoma.
- J-5 微小孔板の超音波振動による液滴生成実験(強力超音波)
- 機能性高分子微粒子の開発 : 帯電性微小球粒子を例として
- (W/O/W)複合エマルションを用いた液中乾燥法による生分解性マイクロカプセルの調製
- スクアレンの酸化劣化に関する検討
- Intramammary Sentinel Lymph Node in Patients with Breast Cancer : Report of Four Cases
- AOT逆ミセル法を用いた温度応答性ナノカプセルの調製
- 感光性高分子に関する基礎研究
- 塩含浸活性炭を芯物質とした生分解性マイクロカプセルの調製
- Configuration of the straight veins and their intramural anastomoses in the human duodenum : an anatomical study using cast specimens
- Synchronous bilateral breast cancer in a male patient following hormone therapy for prostate cancer
- Oncoplastic Surgery After Mammary Reduction and Mastopexy for Bilateral Breast Cancer Lesions : Report of a Case
- Stromal Sarcoma with Features of Giant Cell Malignant Fibrous Histiocytoma
- Metastatic Breast Tumor Arising from Synovial Sarcoma : Report of a Case
- Sudden Hemorrhage without Skin Invasion in a Patient with Breast Cancer : A Case Report and Literature Review
- A Case of Breast Carcinoma with Cartilaginous and Osseous Metaplasia
- Ductal Carcinoma in-Situ of the Breast Detected by [F-18] Fluorodeoxyglucose Positron Emission Tomography
- Adenoma of the Nipple : Report of a Case
- Effect of Nutritional State on Postoperative Axillary Leakage After Axillary Lymph Node Dissection in a New Rat Model
- A Case of Amyotrophic Lateral Sclerosis and Breast Cancer
- Breast Cancer with Nephrotic Syndrome : Report of Two Cases
- Synchronous Bilateral Breast Cancer with Paget's Disease and Invasive Ductal Carcinoma : Report of a Case
- Diffusely Infiltrative Squamous Cell Carcinoma of the Esophagus
- Lymph Node Metastasis and the Recurrence of Esophageal Carcinoma with Emphasis on Lymphadenectomy in the Neck and Superior Mediastinum
- 合成脂質を被覆した二重膜マイクロカプセルの調製とその徐放特性
- 酸化防止剤α-トコフェロール内包マイクロカプセルの調製と化粧品としての応用
- 制癌剤を内包したポリ乳酸マイクロカプセルの表面形態制御 (特集 モノづくりと混相流(3)医療・薬剤技術の進展)
- マイクロリアクターによるマイクロカプセルの調製 (特集 マイクロリアクターの新展開)
- Extraction Equilibrium of Precious Metals from Aqueous Acidic Solutions with Divinylbenzene Homopolymeric Microcapsules Encapsulated Ternary Amine as Core Material
- Surface Morphology Change of Polylactide Microspheres Enclosing Irinotecan Hydrochloride and Its Effect on Release Properties
- 生分解性高分子による遅効性肥料の調製
- 水溶性薬物の徐放制御を目指したマイクロカプセル化技術に関する最近の動向 (特集 材料プロセッシングの展望)
- ポリ乳酸系ブロックポリマーを用いた高分子微粒子製剤の調製 (特集 新技術の創出と機能性材料)
- SPG膜と膨潤法を利用した単分散型高分子ミクロスフェアの開発 : GPC充填剤への応用
- 側鎖型液晶高分子ミクロスフェアの調製
- W/O/W エマルションの液中乾燥法によるポリ乳酸マイクロカプセルへのタンパク質の内包制御
- 低温プラズマグラフト重合法を利用した機能性高分子ミクロスフェアの開発--タンパク質の分離を目指した表面の高機能化を例として (特集 機能性微粒子技術)
- ファインスリットパターンを持つ42アロイのエッチング速度及びファクターに及ぼす操作条件の影響
- 液晶性共重合体ミクロスフィアの調製
- 側鎖型強誘電性液晶ポリマーの合成とそのキャラクターリゼーション
- 縮流ノズルを備えたドラフトチューブ付き噴流層による微紛輸送
- Prognostic performance of the new classification of primary liver cancer of Japan (4th edition) for patients with hepatocellular carcinoma : a validation analysis
- Prognosis of hepatocellular carcinoma associated with Child class B and C cirrhosis in relation to treatment : a multivariate analysis of 411 patients at a single center
- Treatment for Accidental Occlusion of the Hepatic Artery After Hepatic Resection: Report of Two Cases
- 生分解性高分子微粒子の調製プロセス
- I1-3 The role of p27 in cooperation with cyclin E in the prognosis of advanced gastric cancer
- 549 p21 expression is a prognostic factor in p53 negative gastric cancer
- Abnormal Expression of β-and γ-Catenins in Early Gastric Cancer
- 示I-76 The proliferation index of MIB-1, p53 expression and microvessel count in early gastric cancer : association with lymph node metastasis and prognosis
- 247 The adverse role of cyclin E in the progression of early gastric cancer
- The Expression of Cadherin-Catenin Complex in Association with the Clinicopathologic Features of Early Gastric Cancer
- Possibility of prediction lymph node metastasis by combining cadherin-catenin complex and p53 expression in early gastric cancer
- IV-24 Relation between cyclin E expression and clinicopathological features ingastric cancer
- Role of positron emission tomography in decisions on treatment strategies for pancreatic cancer
- A new technique for pancreaticogastrostomy for the soft pancreas : the transfixing suture method
- Ultrasonically activated scalpel is an effective tool for cutting the pancreas in biliary-pancreatic surgery : experimental and clinical studies
- Preoperative assessment of multicentric occurrence in synchronous small and multiple hepatocellular carcinoma based on image-patterns and histological grading of non-cancerous region
- Efficacy of anatomic resection vs nonanatomic resection for small nodular hepatocellular carcinoma based on gross classification
- Postoperative Management Following Massive Hepatectomy in a Patient with Dubin-Johnson Syndrome : Report of a Case
- Endosonographic detection of mediastinal lymph node metastasis in superficial carcinoma of the esophagus : assessment by type classification and histogram
- The Role of Neoadjuvant Radiochemotherapy Using Low-Dose Fraction Cisplatin and 5-Fluorouracil in Patients With Carcinoma of the Esophagus
- Does Preoperative Chemotherapy Cause Adverse Effects on the Perioperative Course of Patients undergoing Esophagectomy for Carcinoma?
- Spindle cell carcinoma of the pancreas
- Gene expression of gastric type mucin (MUC5AC) in pancreatic tumors : Its relationship with the biological behavior of the tumor
- MUC-1 mucin expression in invasive areas of intraductal papillary mucinous tumors of the pancreas
- 膜乳化法によるエマルションの調製 (液膜分離技術と応用)
- 縮流ノズルを用いる微粉の輸送特性
- DISTRIBUTION EQUILIBRIUM OF PALLADIUM BETWEEN AQUEOUS HYDROCHLORIC A CID SOLUTION AND TRI-n-OCTYLAMINE IN TOLUENE
- 低温プラズマによる高分子ミクロスフィアの帯電制御
- スプレー式エッチングの特性に及ぼす操作条件の影響
- ニッケル/鉄合金のウェットエッチング速度
- 高分子微粒子の表面機能化はどこまで進んでいるか (特集2 粉体の高機能化と環境対策)
- 単分散ポリマ-微粒子の開発 (特集 新しい研究開発と課題)
- ゼラチン/アラビアゴム系複合コアセルベーション法による多層膜マイクロカプセルの調製
- 制癌剤内包ミクロスフィアに及ぼすγ線照射の影響
- 42アロイのスプレー式エッチングにおけるエッチング液性の影響
- 中空マイクロカプセルの調製
- NOVEL PROCEDURE FOR MONODISPERSED POLYMERIC MICROSPHERES WITH HIGH ELECTRIFYING ADDITIVE CONTENT BY PARTICLE-SHRINKING METHOD VIA SPG MEMBRANE EMULSIFICATION
- PERMEABILITY CONTROL OF ACTIVE AGENT FROM POLYMERIC MICROCAPSULES BY COATING OF GELATIN/GUM ARABIC MEMBRANE
- 制癌剤担持生分解性高分子微粒子の調製 (進展する微粒子技術の話題)
- PREPARATION OF DIVINYLBENZENE HOMOPOLYMERIC MICROCAPSULES WITH HIGHLY POROUS MEMBRANES BY IN SITU POLYMERIZATION WITH SOLVENT EVAPORATION
- pH-SENSITIVE RELEASE FROM POLY(ACRYLAMIDE-CO-N, N'-METHYLENE BISACRYLAMIDE)MICROSPHERES
- 溶媒抽出と吸着樹脂との融合技術--抽出マイクロカプセルによる物質分離
- Expression of Thrombomodulin in Esophageal Squamous Cell Carcinoma Cell Lines
- Asymptomatic Somatostatinoma of the Pancreatic Head : Report of a Case
- Extraction of Ethyl Ester of Polyunsaturated Fatty Acids by Utilizing Slug Flow Prepared by Microreactor
- ELECTROSTATIC PROPERTIES OF POLY (STYRENE-CO-DIVINYLBENZENE) MICROSPHERES WITH DIFFERENT SURFACE MORPHOLOGIES
- ELECTROSTATIC CHARACTERIZATION OF POLYMERIC MICROSPHERES CONTAINING ELECTRIFYING ADDITIVES
- CONTROLLED RELEASE OF STYRENE-DIVINYLBENZENE COPOLYMER MICROCAPSULES BY PHASE TRANSFORMATION OF ENCAPSULATED STEARIC ACID
- REGENERATION OF STYRENE-DIVINYLBENZENE COPOLYMER MICROCAPSULES CONTAINING TRI-N-OCTYL AMINE
- PREPARATUON AND EXTRACTION PROPERTIES OF MICROCAPSULES CONTAINING TRI-N-OCTYL AS CORE MATERIAL AMINE
- 液晶性高分子ミクロスフィアの調製 (微粒子設計の応用)
- 機能性マイクロカプセル調製 (新素材・材料開発の展望)
- Increased Midkine Gene Expression in Human Gastrointestinal Cancers
- The Invasion-MTT Assay as a Predictor of Liver Metastasis Using Human Gastrointestinal Carcinomas Transplanted in Nude Mice
- B7-H3 expression in gastric cancer : A novel molecular blood marker for detecting circulating tumor cells