各種抗菌薬に対する臨床分離株の感受性サーベイランス : 2000年分離グラム陽性球菌および嫌気性菌に対する抗菌力

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The activity of various antibacterial agents against clinical isolates of 1, 126 strains of gram-positive cocci (30 species) and 166 strains of anaerobic bacteria (23 species) was assessed by determining their agar-dilution MICs. The strains tested, were clinical isolates obtained in 2000 at 16 facilities in Japan. Methicillin-resistant strains accounted for 61.5% of the Staphylococcus aureus and for 82.0% of the Staphylococcus epidermidis. Arbekacin (ABK), quinupristin/dalfopristin (QPR/DPR), and vancomycin (VCM) had high antibacterial activity against methicillin-resistant S. aureus (MRSA) and methicillin-resistant S. epidermidis (MRSE), with MIC90 values≤1.56μg/mL. Penicillin (PC)-intermediate strains and PC-resistant strains accounted for 27.3% and 30.5%, respectively, of the Streptococcus pneumoniae. Cefpirome, carbapenems (CBPs), VCM, teicoplanin (TEIC), and QPR/DPR displayed high antibacterial activity against PRSP, inhibiting the growth of all strains at≤0.78μg/mL. VCM, TEIC, and linezolid were effective against Enterococcus faecalis and Enterococcus faecium with MTC90 values≤3.13μg/mL. No VCM-resistant strains were found among the gram-positive coccus isolates tested, including MRSA, MRSE, and Enterococcus species, except Enterococcus casseriflavus and Enterococcus gallinarum. However, TEIC-resistant strains were detected in some species, such as MRSE and Staphylococcus haemolyticus. Among the anaerobes, CBPs displayed potent antibacterial activity against all anaerobic bacteria, however, the decrease in susceptibility of Bacteroides fragilis and Prevotella spp. to CBPs should be noted.
公益社団法人日本化学療法学会の論文
2003-04-25

各種抗菌薬に対する臨床分離株の感受性サーベイランス : 2000年分離グラム陽性球菌および嫌気性菌に対する抗菌力

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