日進月歩のパラジウム, ニツケル触媒の化学 : 増大する有機合成化学へのインパクト

概要

論文の詳細を見る
Recent remarkable progress in palladium and nickel-catalyzed reactions and its increasing impact on organic synthesis are surveyed. Aryl chlorides, which have been regarded as inactive compounds in nucleophilic substitutions, undergo facile Pd-catalyzed substitition. In these reactions of aryl chlorides, use of bulky and electron-rich ligands, typically tri (<I>tert</I>-butyl) phosphine, are important. Pd-catalyzed amination, Mizonoki-Heck reaction, Suzuki-Miyaura coupling, Sonogashira reaction, α-arylation of ketones with aryl chlorides proceed smoothly using various bulky and electron-rich ligands. Also active Pd catalysts are prepared by coordination of stable <I>N</I>-heterocyclic carbene ligands. Ni-phosphine complexes, impregnated on carbon were found to be very active catalysts for the substitution of aryl chlorides.
社団法人有機合成化学協会の論文
2001-06-01