ケミカルプローブを用いた創薬ターゲットの同定

概要

論文の詳細を見る
The completion of the human genome project brings a paradigm shift for drug discovery. It has been said that use of genomic information could accelerate the identification of new drug targets and the development of tailor-made drugs. Rising new technologies, such as transcriptomics (DNA microarray analysis), proteomics and bioinformatics, have made it possible to analyze a global expression of genes and proteins and compare their difference between normal and disease conditions. But it is also become evident that such flood of enormous data is not necessarily prerequisite for new drug discovery, especially for drug target identification. Chemical compounds with pharmacological activities appear to be one of the key tools to narrow down druggable targets on the basis of their interaction with cellular proteins and their effects on gene and protein expression. Here we show recent technologies that exploit chemical probes for identifying promising drug target proteins.
日本質量分析学会の論文
2003-10-01