プロテオミクスの展望 : 夢物語に終わらないために

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Although the word “Proteome” also appeared in 1995 for the first time, it was hardly observed at that time. On the other hand, some papers about a microarray were released at the same time. The microarray has spread in an instant, and although there is the side in which it is troubled by the interpretation for too much a vast quantity of data, the information which transcriptomics brings about is achieving success certainly, and greatly has begun to contribute not only to drug discovery but to the life science field. Then, how is it about proteomics? Although the result has appeared in the search for a clinical marker for a serum sample without genome, there is almost no example of a success which contributed to life science in proteome analysis. In a transcriptomics and proteomics, a difference is in the amount of information acquired too much. The current proteomics understands only a part very much. Furthermore, proteomics is greatly inferior also in through-put. Just the information which cannot be acquired only from a gene is considered to be the directivity of future proteomics. Therefore, we should focus on protein-complex analysis, post-translational modification study etc. and then should contribute to life science by performing more practical proteomics. The key of future proteomics is pursued not only in proteomics but in all fields about high speed, quantity sensitivity, automation, and information processing. Since it has already turned into fixed form business about identification of the protein using MS, it is a point how it utilizes well in a life science field. Application of chemical design like ICAT and genetic design like TAP are expected in a technical side. And breakthroughs, such as development of a protein chip which is located in a line with a DNA chip, and an amplification means of the protein equivalent to PCR, may also appear suddenly.
日本質量分析学会の論文
2002-06-01

プロテオミクスの展望 : 夢物語に終わらないために

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