Matrix Effects on the Chiral Recognition Determined by the Relative Peak Intensity of Diastereomeric Host-Guest Complex Ions Using the FAB Mass Spectrometry/Enantiomer Labeled Guest Method

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概要

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• The FAB mass spectrometry (MS)/enantiomer labeled (EL) guest method is one of the useful technique to easily evaluate chiral discrimination ability of a chiral host (H) toward chiral guests (GR+, GS-dn+). In this paper, the matrix dependency of the relative peak intensity (IRIS) of the diastereomeric host-guest complex ions [(H+GR)+ and (H+GS-dn)+] was investigated (host, MeFruNys; guest, Phe-O-iPr+). The IRIS values of spectra measured using NBA, NPOE, and DTDE matrices agreed almost with the ratio of concentrations of the complex ions calculated from the association constants (KR and KS) in chloroform at 298 K. While, the IRIS values of spectra using glycerol matrix reached almost unity. It was assumed that the IRIS values depend upon the matrices used since the difference of solvation ability of the matrices affects the actual concentration of the guest concerning in the complexation. And then, it was recommended that NBA is the best matrix for chiral recognition mass spectrometry studies.

• 日本質量分析学会の論文
• 2002-12-01

著者

• Shizuma Motohiro

  Technochemistry Osaka Municipal Technical Research Institute

• SHIZUMA Motohiro

  Department of Biochemistry, Osaka Municipal Technical Research Institute

• TAKAI Yoshio

  Materials Analysis Center, The Institute of Scientific and Industrial Research, Osaka University

• Takeda Yuka

  Department Of Applied Chemistry & Biochemistry Faculty Of Engineering Kumamoto University

• Takai Y

  Materials Analysis Center The Institute Of Scientific And Industrial Research Osaka University

• Takai Y

  The Institute Of Scientific And Industrial Research Osaka University

• Takai Yoshio

  Materials Analysis Center The Institute Of Scientific And Industrial Research Osaka University

• Sawada M

  Materials Analysis Center The Institute Of Scientific And Industrial Research Osaka University

• Sawada Masami

  Materials Analysis Center The Institute Of Scientific And Industrial Research Osaka University

• YAMADA Hitoshi

  Materials Analysis Center, The Institute of Scientific and Industrial Research, Osaka University

• ADACHI Hiroshi

  Faculty of Science, Osaka University

• TAKEDA Tokuji

  Technochemistry Department, Osaka Municipal Technical Research Institute

• Shizuma Motohiro

  Department Of Biochemistry Osaka Municipal Technical Research Institute

• Takeda Tokuji

  Technochemistry Department Osaka Municipal Technical Research Institute

• Yamada Hidetoshi

  Materials Analysis Center The Institute Of Scientific And Industrial Research Osaka University

• Takai Y

  Toyama Univ. Toyama

• Adachi Hiroshi

  Faculty Of Science Osaka University

• Takai Yoshio

  Material Analysis Center, The Institute of Scientific and Industrial Research, Osaka University

• SAWADA Masami

  Material Analysis Center, The Institute of Scientific and Industrial Research, Osaka University

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