A Light Microscopic Radioautographic Study on Protein Synthesis in Pulmonary Cells of Aging Mice
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概要
- 論文の詳細を見る
In the present study we first investigated the changes in protein synthesis of respective cell types of mouse pulmonary alveoli from 16 days of fetal life to senility (postnatal 22 months) by using <SUP>3</SUP>H-leucine light microscopic radioautography. The results revealed that the protein syntheses in type I epithelial cells, type II epithelial cells, interstitial cells and endothelial cells in the mouse lung changed due to aging. The protein synthesis of type I epithelial cells was the highest on postnatal day 1, increased again at 1 week after birth, and then decreased gradually to 22 months after birth with aging. The protein syntheses of type II epithelial cells, interstitial cells and endothelial cells reached the highest level on fetal day 16, declined progressively with age, and increased again at postnatal 1 week, and then decreased gradually from 2 weeks to senility. Our results suggest that the decreases in protein synthesis are correlated with the decremental changes in DNA and RNA synthesis in the lung with aging.
- 日本組織細胞化学会の論文
- 1997-10-01
著者
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SUN Lin
Pathology Division, National Cancer Center Research Institute
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Sun Lin
Department Of Anatomy And Cell Biology Shinshu University School Of Medicine
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Sun Lin
Pathology Division National Cancer Center Research Institute
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Nagata Tetsuji
Departmenrts Of Anatomy And Cell Biology Shinsyu University School Of Medicine
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Nagata Tetsuji
信州大学 医学部解剖学
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Gao Fulu
Department Of Histology And Embryology Chengde Medical Colldge
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