Central Nervous System-Mediated Hyperglycemic Effects of NIK-247, a Cholinesterase Inhibitor, and MKC-231, a Choline Uptake Enhancer, in Rats
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概要
- 論文の詳細を見る
We investigated the effects of intracerebroventricular administration of NIK-247 (9-amino-2, 3, 5, 6, 7, 8-hexahydro-1H-cyclo-penta(b)-quinoline monohydrate hydrochloride; a cholinesterase inhibitor) or MKC-231 (2-(2-oxypyrrolidin-l-yl)-N-(2, 3-dimethyl-5, 6, 7, 8-tetrahydrofuro[2, 3-b]quinolin-4-yl) acetoamide; a choline uptake enhancer) on plasma glucose level in comparison with that of neostigmine administration in rats. The extents of NIK-247- and MKC-231-induced hyperglycemia were considerably less than that by neostigmine, suggesting that the potencies of the drugs to produce the peripheral hyperglycemia may be pharmacologically negligible.
- 社団法人 日本薬理学会の論文
著者
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Hotta Nigishi
Department of Cardiology, Chubu-Rosai Hospital
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Iguchi Akihisa
Department of Geriatrics, Nagoya University Graduate School of Medicine
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Iguchi Akihisa
Department Of Geriatrics Medicine In Growth And Aging Program In Health And Community Medicine Nagoy
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Hotta Nigishi
Department Of Cardiology Chubu-rosai Hospital
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Hotta Nigishi
Department Of Geriatric Medicine Nagoya University School Of Medicine
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Uemura Kazumasa
Third Department Of Internal Medicine Nagoya University School Of Medicine
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Tamagawa Tatsuo
Third Department Of Internal Medicine Nagoya University School Of Medicine
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YOSHIOKA SHUKO
Third Department of Internal Medicine, Nagoya University School of Medicine
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Yoshioka Shuko
Third Department Of Internal Medicine Nagoya University School Of Medicine
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SURINA-BAUMGARTNER Denise
Third Department of Internal Medicine, Nagoya University School of Medicine
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MIURA Hisayuki
Department of Geriatric Medicine, Nagoya University School of Medicine
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UEDA Muneto
Department of Geriatric Medicine, Nagoya University School of Medicine
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TAMAYA Norika
Department of Geriatric Medicine, Nagoya University School of Medicine
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Tamaya Norika
Laboratory Animal Research Facilities (larf) National Institute For Longevity Sciences (nils)
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Ueda Muneto
Department Of Geriatrics Medicine In Growth And Aging Program In Health And Community Medicine Nagoy
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Miura Hisayuki
Department Of Geriatrics Medicine In Growth And Aging Program In Health And Community Medicine Nagoy
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Surina-baumgartner Denise
Third Department Of Internal Medicine Nagoya University School Of Medicine
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