Serum levels of KL-6 reflect disease activity of interstitial pneumonia associated with ANCA-related vasculitis

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概要

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• Objective. KL-6 is reported to be excreted from the lung alveolar and bronchial epithelial cells and may be a good marker for monitoring disease activity of interstitial pneumonia. This study was designed to ascertain the clinical significance of serum KL-6 levels in interstitial pneumonia associated with anti-neutrophil cytoplasmic antibody (ANCA)-related vasculitis. Methods. Serum KL-6 levels were determined by an enzyme-linked immunosorbent assay. Patients. We examined 20 healthy subjects, 13 patients with perinuclear (myeloperoxidase, MPO) ANCA-related vasculitis and 12 dermatomyositis (DM)/polymyositis (PM) patients as disease controls in this study. Six out of 13 patients with ANCA-related vasculitis had interstitial pneumonia. Results. Serum levels of KL-6 in ANCA-positive patients with interstitial pneumonia were significantly elevated, while they remained as low as those of healthy subjects in ANCA- positive patients without interstitial pneumonia. Similarly, KL-6 levels in sera were higher in 12 dermatomyositis/polymyositis patients with interstitial pneumonia, while they remained low in DM/PM patients without interstitial pneumonia. Moreover, the elevated serum KL-6 level was reduced during the convalescence induced by glucocorticoid therapy and reflected the disease activity of interstitial pneumonia associated with ANCA-related vasculitis. Conclusion. These data suggest that the measurement of serum KL-6 levels may be a good monitoring system for the diagnosis and follow-up of interstitial pneumonia of patients with ANCA-related vasculitis.

• The Japanese Society of Internal Medicine = 日本内科学会の論文

著者

• Yokoyama Hitoshi

  金沢大学 医学系研究科恒常性制御学

• Wada Takashi

  金沢大学 医学部血液浄化療法部

• Furuichi K

  金沢大学 医学系研究科恒常性制御学

• Furuichi Kengo

  Kanazawa Univ. Hospital Kanazawa Jpn

• Yokoyama H

  Division Of Blood Purification Department Of Gastroenterology And Nephrology Graduate School Of Medi

• Wada Takashi

  Kanazawa Univ. Graduate School Of Medical Sci. Kanazawa Jpn

• Iwata Yasunori

  The Department Of Gastroenterology And Nephrology

• Sakai Norihiko

  Division Of Blood Purification Graduate School Of Medical Science Kanazawa University

• Sakai Norihiko

  The Department Of Gastroenterology And Nephrology

• Sakai Norihiko

  富山県立中央病院

• Kokubo Satoshi

  The Department Of Gastroenterology And Nephrology

• YOKOYAMA Hitoshi

  Division of Blood Purification, Kanazawa University Hospital

• Shimizu Miho

  The Department Of Gastroenterology And Nephrology

• Wada T

  Division Of Blood Purification Department Of Gastroenterology And Nephrology Graduate School Of Medi

• WADA Takashi

  The Department of Gastroenterology and Nephrology

• FURUICHI Kengo

  The Department of Gastroenterology and Nephrology

• KITAGAWA Kiyoki

  The Department of Gastroenterology and Nephrology

• KOBAYASHI Motoo

  The Department of Gastroenterology and Nephrology

• YOSHIMOTO Keiichi

  The Department of Gastroenterology and Nephrology

• KOBAYASHI Ken-ichi

  The Department of Gastroenterology and Nephrology

• Kobayashi Ken-ichi

  Department Of Gastroenterology And Nephrology Kanazawa University Graduate School Of Medicine

• Kobayashi Ken-ichi

  The Department Of Endocrinology And Metabolism (first Department Of Internal Medicine) Kanazawa Univ

• Wada Takashi

  Department Of Laboratory Medicine Kanazawa University Graduate School Of Medical Science

• Wada T

  Department Of Laboratory Medicine Graduate School Of Medical Science Kanazawa University

• Kobayashi K

  Toyama Univ. Toyama

• Yoshimoto Keiichi

  Division Of Blood Purification Department Of Gastroenterology And Nephrology Graduate School Of Medi

• Kobayashi Kenichi

  the Department of Endocrinology and Metabolism (First Department of Internal Medicine), Kanazawa University Graduate School of Medical Science

• Yokoyama Hitoshi

  Division of Blood Purification, Department of Gastroenterology and Nephrology, Graduate School of Medical Science, Kanazawa University

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