A Case of Chronic Hepatitis C with Nephrotic Diabetic Nephropathy who Achieved Sustained Viral Remission by Double-Filtration Plasmapheresis and Interferon Combination Therapy

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概要

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• We report a 66-year-old man with chronic hepatitis caused by hepatitis type C virus of genotype-1b and high-viral-load combined with cryoglobulinemia and advanced diabetic nephropathy in whom we successfully achieved viral removal and eradication by DFPP (VRAD). The dose of PEG-interferon was reduced to 70 mg/week due to thrombocytopenia. Rivavirin was discontinued at day 21 due to anemia. Even with treatment of PEG-interferon alone, the condition was judged to be sustained viral remission at the end of the observation. This is a successful report of VRAD in a combined case of diabetic and HCV-related cryoglobulin-nephropathy with nephrotic syndrome. The therapeutic effect of IFN seemed to be efficiently enhanced by concomitant DFPP (VRAD therapy).

著者

• Nakagawa Masaru

  Division Of Internal Medicine Toneyama National Hospital

• Yamaya Hideki

  Division Of Nephrology Kanazawa Medical University School Of Medicine

• Chikazawa Yoshihiro

  Division Of Nephrology Department Of Internal Medicine Kanazawa Medical University

• Okuyama Hiroshi

  Division Of Cardiology Department Of Internal Medicine And Physiolocly Juntendo Univercity

• Yokoyama Hitoshi

  Division of Blood Purification, Department of Gastroenterology and Nephrology, Graduate School of Medical Science, Kanazawa University

• Imura Junko

  Division of Nephrology, Kanazawa Medical University School of Medicine, Japan

• Kimura Syogo

  Division of Nephrology, Kanazawa Medical University School of Medicine, Japan

• Fujimoto Keiji

  Division of Nephrology, Kanazawa Medical University School of Medicine, Japan

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