Adrenocortical Insufficiency Associated with Long-term High-dose Fosfestrol Therapy for Prostatic Carcinoma

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概要

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• A 59-year-old man was admitted to our hospital because of muscular pain, weakness, and anorexia. He had been treated with 600 mg/day of fosfestrol, a synthetic estrogen, for 10 years for prostatic carcinoma. Endocrinological studies demonstrated adrenocortical insufficiency due to inadequate ACTH secretion. After initiation of glucocorticoid replacement therapy, his symptoms subsided rapidly. To our knowledge, an association between estrogenic agents, including fosfestrol, and secondary adrenocortical insufficiency has not been previously reported. Physicians who treat patients with long-term and high-dose strong estrogenic agents should be cautious about the possible emergence of secondary adrenocortical insufficiency.(Internal Medicine 38: 804-807, 1999)

• 社団法人 日本内科学会の論文

著者

• NAGAI YUKIHIRO

  The First Department of Internal Medicine, School of Medicine, Kanazawa University

• Iida Hiroshi

  The Division of Cardiology, Tokuyama Central Hospital

• Nagai Yukihiro

  The First Department Of Internal Medicine School Of Medicine Kanazawa University

• Noda Yatsugi

  The Department Of Internal Medicine Toyama Rohsai Hospital

• MIYAMOTO Ichiro

  the Department of Internal Medicine, Toyama Rohsai Hospital

• SAWAKI Masaru

  the Department of Urology, Toyama Rohsai Hospital

• Sawaki Masaru

  The Department Of Urology Toyama Rohsai Hospital

• Miyamoto Ichiro

  The Department Of Internal Medicine Toyama Rohsai Hospital

• Iida Hiroshi

  The Department Of Internal Medicine Toyama Rohsai Hospital

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