Exacerbation of Hypothyroidism Following Tumor Necrosis Factor-.ALPHA. Infusion.
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概要
- 論文の詳細を見る
A46-year-old woman with chronic thyroiditis who had been receiving thyroid hormone treatment for 10yr developed severe hypothyroidism (FT4 0.37ng/dl, FT3 1.38pg/ml, TSH 151.00μU/ml) following tumor necrosis factor-α (TNF) infusion for the treatment of a complicated cutaneous T-cell lymphoma. Indirect immunofluorescence staining of thyroid follicular cells showed aberrant expression of HLA class II antigens. The mechanisms underlying the exacerbation of the hypothyroidism may be an augmentation of immunological processes in the thyroid and a direct action of TNF on the synthesis and secretion of thyroid hormone.(Internal Medicine 31 : 200-203, 1992)
- 社団法人 日本内科学会の論文
著者
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Nagai Yukihiro
The First Department Of Internal Medicine School Of Medicine Kanazawa University
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Yokoyama Hitoshi
The First Department Of Internal Medicine School Of Medicine Kanazawa University
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Kobayashi Ken-ichi
The First Department Of Internal Medicine Faculty Of Medicine Kanazawa University
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BANDO Yukihiro
The First Department of Internal Medicine, School of Medicine, Kanazawa University
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MIYAKOSHI Hisatsugu
The First Department of Internal Medicine, School of Medicine, Kanazawa University
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OHSAWA Kensô
The First Department of Internal Medicine, School of Medicine, Kanazawa University
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IEKI Yasuhiko
The First Department of Internal Medicine, School of Medicine, Kanazawa University
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- Exacerbation of Hypothyroidism Following Tumor Necrosis Factor-.ALPHA. Infusion.