重合性リン脂質の特性と利用

概要

論文の詳細を見る
Characteristics and their uses of polymerizable phospholipids were described. Most phospholipids usually form vesicles whereas one possessing diacetylenic group forms tubule. Polymerization is performed to stabilize vesicles for prolonged or controlled release of ingredients. Among them hemoglobin encapsulated liposome were developed for artificial red blood cells using conjugated diene type phospholipids. Polymerization profile, physical stability and <I>in vivo</I> safety tests such as hematological or immunological study were described. In addition to performing good physical stability, polymerized liposomal hemoglobin (ARC) show good compatibility with blood. Although ARC affected on immunological system for several days after injec tion, the change was temporary. Methacrylic type phospholipids were also studied as biocompat ible materials. Surface coated with copolymer (BMA) show less precipitation of blood cells or proteins after contact with whole blood. It seemed that polymerized materials containing phos phoryl choline group were well tolerated in livings. Many kinds of these products are expected on the market in the near future.
社団法人日本油化学会の論文
1995-10-20