第6回若手奨励賞受賞論文心サルコイドーシス診断の手引きにおける各種診断モダリティーの検討

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Background : Sarcoidosis is a multiple organ granulomatous disease of undefined cause. Althoughcardiac involvement often leads to adverse outcomes in patients with sarcoidosis, diagnosisof cardiac sarcoidosis（CS）remains difficult due to the lack of sensitive diagnostic tests.Purpose : To determine an appropriate combination of diagnostic tests for detecting CS.Method and Results : Thirteen patients were diagnosed with CS from December ２００６ toNovember２０１０by the use of２００６revised guidelines for diagnosing CS of the Japanese Society ofSarcoidosis and Other Granulomatous Disorders. Positive rate of each major or minor criterion inthe guidelines was examined. We also evaluated positive rate of each diagnostic test. In the majorcriteria, basal thinning of the ventricular septum showed a high positive rate of７１．４％, although theothers were less than５０％. In the minor criteria, positive rates of abnormal electrocardiogram findingsand abnormal echocardiogram were７６．９％ and８４．６％, respectively. Late gadolinium enhancement（LGE）of the myocardium on cardiac MRI scanning（CMR）showed a positive rate of１００％ ; however,CMR was not performed in four patients due to life-threatening arrhythmia. All１３patients showedabnormal findings at least in either echocardiogram or LGE on CMR.Conclusion : Echocardiography is a convenient diagnostic test for detecting CS. The combinationof cardiac MRI and echocardiography may improve diagnostic sensitivity.
徳島医学会の論文
2011-12-20

第6回若手奨励賞受賞論文心サルコイドーシス診断の手引きにおける各種診断モダリティーの検討

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第6回若手奨励賞受賞論文 心サルコイドーシス診断の手引きにおける各種診断モダリティーの検討

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第6回若手奨励賞受賞論文心サルコイドーシス診断の手引きにおける各種診断モダリティーの検討