Simple Fabrication of Gd(III)-DTPA-Nanodiamond Particles by Chemical Modification for Use as Magnetic Resonance Imaging (MRI) Contrast Agent
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概要
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We have developed a simple and useful process for fabricating nanodiamond (ND) particles modified with an organogadolinium moiety by chemical modification for their use as a magnetic resonance imaging (MRI) contrast agent. The introduction of the organogadolinium moiety on the surface of the ND particles was performed by the condensation of ND and diethylenetriaminepentaacetic acid (DTPA) followed by treatment with GdCl3. The modified surfaces were evaluated by X-ray photoelectron spectroscopy, diffuse reflectance Fourier transform infrared spectroscopy, mass spectroscopy, and inductively coupled plasma atomic emission spectroscopy analyses. MRI experiments on the Gd-DTPA-ND particles indicated their high signal intensity on T1-weighted images.
- 2013-01-25
著者
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OHANA Tsuguyori
National Institute of Advanced Industrial Science and Technology (AIST)
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Nakamura Takako
National Institute Of Advanced Industrial Science And Technology
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Suzuki Tetsuya
Center for Science of Environment, Resources and Energy, Graduate School of Science and Technology, Keio University, Yokohama 223-8522, Japan
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HASEBE Terumitsu
Center for Science of Environment, Resources and Energy, Graduate School of Science and Technology, Keio University
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YABUNO Hajime
Center for Science of Environment, Resources and Energy, Graduate School of Science and Technology, Keio University
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KASAI Rumiko
Department of Radiology, Toho University Sakura Medical Center
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Kasai Rumiko
Department of Radiology, Toho University Sakura Medical Center, Sakura, Chiba 285-8741, Japan
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Yabuno Hajime
Center for Science of Environment, Resources and Energy, Graduate School of Science and Technology, Keio University, Yokohama 223-8522, Japan
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- Simple Fabrication of Gd(III)-DTPA-Nanodiamond Particles by Chemical Modification for Use as Magnetic Resonance Imaging (MRI) Contrast Agent
- Simple Fabrication of Gd(III)-DTPA-Nanodiamond Particles by Chemical Modification for Use as Magnetic Resonance Imagina (MRI) Contrast Agent