Study of the Line Optical Tweezers Characteristics Using a Novel Method and Establishing a Model for Cell Sorting

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概要

• 論文の詳細を見る

• Optical tweezers have become a powerful tool in cellular and molecule biology. Line optical tweezers enhanced its function in cell sorting. This study presents the line trap model, based on the ray-optics model, and demonstrates its accuracy for the line optical tweezers. The line optical tweezers system is established to produce the optical intensity distribution of a line pattern and to trap the micro-sized beads. The main parameter, optical intensity distribution, is used to calculate the trapping force distribution in the model. The two forces, trapping force and water dragging force, and the equation of motion is used to simulate the trajectory of micro-sized beads as they pass through the line pattern in flowing water in the microchannel. The trajectory is analyzed to determine the effective separation distance between the micro-sized beads or cells. The method will be applied in biological and medical detection.

• Published by the Japan Society of Applied Physics through the Institute of Pure and Applied Physicsの論文
• 2009-07-25

著者

• Lin Ho-Chien

  Institute and Department of Electrophysics, National Chiao-Tung University, 1001 Ta Hsueh Road, Hsinchu, Taiwan 30010, R.O.C.

• Hsu Long

  Institute and Department of Electrophysics, National Chiao-Tung University, 1001 Ta Hsueh Road, Hsinchu, Taiwan 30010, R.O.C.

関連論文

• Study of the Line Optical Tweezers Characteristics Using a Novel Method and Establishing a Model for Cell Sorting
• Measurement of Macrophage Adhesion at Various pH Values by Optical Tweezers with Backward-Scattered Detection

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