Design and Fabrication of Nanostructures Based on DNA Ring–Protein Complex

概要

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In this report, we describe the design and fabrication of DNA nanostructures ("DNA glasses", "DNA serial rings", and "DNA chains") using DNA ring–protein complexes. An experiment was performed to fabricate DNA ring-conjugated biotin using two types of DNA ("vector DNA" and "insert DNA"). The vector DNA was obtained by cutting plasmid DNA with restriction enzymes. The insert DNA (DNA conjugated with biotin) was obtained using a DNA synthesizer. After ligation and the introduction of streptavidin-modified gold nanoparticles, DNA structures were obtained. Subsequently, the DNA structures were observed by atomic force microscopy (AFM).
Published by the Japan Society of Applied Physics through the Institute of Pure and Applied Physicsの論文
2008-06-25