Detection of Molecular Charges at Cell Membrane

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概要

• 論文の詳細を見る

• Molecular charges at the cell membrane have been successfully detected using cell-based field-effect devices. Mouse fibroblast cells were adhered to the Si3N4 gate surface of the field-effect devices. The negative charges of sialic acid at the surface of the cell membrane could be detected as a shift of the flatband voltage of the field-effect devices. Quantitative analysis of molecular charges at the cell membrane could be demonstrated in relation to the number of adhered cells on the Si3N4 gate surface. The platform based on the field-effect devices is suitable for a simple, accurate and non-invasive system for cell functional analysis.

• Published by the Japan Society of Applied Physics through the Institute of Pure and Applied Physicsの論文
• 2008-01-25

著者

• Miyahara Yuji

  Center For Nanobio Integration The Univ. Of Tokyo

• Sakata Toshiya

  Center For Nanobio Integration The University Of Tokyo

• Sakata Toshiya

  Center for NanoBio Integration, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan

関連論文

• Capacitance-voltage measurement of transporting function at cell membrane (特集 インテリジェントバイオチップ)
• Potential Behavior of Biochemically Modified Gold Electrode for Extended-Gate Field-Effect Transistor
• Potential Behavior of Bio-Chemically Modified Electrode for Extended Gate Field Effect Transistor
• Cell Adhesion Characteristics of Chemically Modified Silicon Nitride Surfaces
• Detection of Molecular Charges at Cell Membrane

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