Indocyanine Green-lactosome and Near-infrared Light-based Intraoperative Imaging and Photodynamic Therapy for Metastatic Bone Tumors

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概要

• 論文の詳細を見る

• The reduction of local recurrence of metastatic spinal tuomors after intratumoral excision improves the quality of life. We have developed a novel photodynamic therapy (PDT) comprising an indocyanine green (ICG)-labeld nanocarrier (ICG-lactosome) and near-infrared light for use as an intraoperative adjuvant therapy. ICG-lactosomes accumulated in bone metastases from breast cancer because of enhanced permeability and retention effect. The cytotoxic effects of this novel PDT on human breast cancer cells were confirmed. In conclusion, ICG-lactosomes enable selective tumor imaging and represent a potential new PDT photosensitizer for adjuvant therapy during surgery for bone metastases from human breast cancer.

• The Society of Photopolymer Science and Technology (SPST)の論文

著者

• Ozeki Eiichi

  Technology Research Laboratory Shimadzu Corporation

• Sakane Masataka

  Department Of Orthopaedic Surgery Graduate School Of Comprehensive Human Sciences University Of Tsuk

• Funayama Toru

  Department Of Orthopaedic Surgery Graduate School Of Comprehensive Human Sciences University Of Tsuk

• Abe Tetsuya

  Department Of Biochemistry School Of Medicine University Of Occupational And Environmental Health

• Yamazaki Masashi

  Department of Chemistry, Faculty of Science and Technology, Sophia University

• Hara Isao

  Technology Research Laboratory, Shimadzu Corporation

• Tsukanishi Toshinori

  Department of Orthopaedic Surgery, University of Tsukuba

• Onishi Shinzo

  Department of Orthopaedic Surgery, University of Tsukuba

• Funayama Toru

  Department of Orthopaedic Surgery, Kempoku Medical Center Takahagi Kyodo Hospital

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